Seroatlas · Human Serome Atlas

C1orf50

Uncharacterized protein C1orf50

Also known as: CA050_HUMAN, MGC955

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV19
Gene: C1orf50
Ensembl: ENSG00000164008
Chromosome: 1
Canonical length: 199 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9BV19|C1orf50
     1  MEDAAAPGRT EGVLERQGAP PAAGQGGALV ELTPTPGGLA LVSPYHTHRA GDPLDLVALA
    61  EQVQKADEFI RANATNKLTV IAEQIQHLQE QARKVLEDAH RDANLHHVAC NIVKKPGNIY
   121  YLYKRESGQQ YFSIISPKEW GTSCPHDFLG AYKLQHDLSW TPYEDIEKQD AKISMMDTLL
   181  SQSVALPPCT EPNFQGLTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6.7 nTPM
bone marrow: 3.5 nTPM
tongue: 2.9 nTPM
retina: 2.8 nTPM
cerebral cortex: 2.6 nTPM
midbrain: 2.5 nTPM

Single-cell type

late spermatids: 1.7 nCPM
mucous neck cells: 0.8 nCPM
thymocytes: 0.8 nCPM
hematopoietic stem cells: 0.5 nCPM
megakaryocyte progenitors: 0.5 nCPM
pituitary stem cells: 0.5 nCPM

Immune cell

non-classical monocyte: 1.6 nTPM
basophil: 1 nTPM
plasmacytoid DC: 0.8 nTPM
eosinophil: 0.6 nTPM
neutrophil: 0.6 nTPM
gdT-cell: 0.5 nTPM

Brain region

hypothalamus: 8 nTPM
spinal cord: 7.3 nTPM
white matter: 7.3 nTPM
basal ganglia: 7.2 nTPM
medulla oblongata: 7 nTPM
midbrain: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.03
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF2452
Protein of unknown function (DUF2452)

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of C1orf50 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AHCY

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf50 as an antibody target. Whether an autoantibody or antibody against C1orf50 could matter depends on whether native C1orf50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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