Seroatlas · Human Serome Atlas

C1orf43

Protein C1orf43

Also known as: CA043_HUMAN, DKFZp586G1722, NICE-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BWL3
Gene
C1orf43
Ensembl
ENSG00000143612
Chromosome
1
Canonical length
253 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria,Cytosol

OverviewNCBI Gene

Involved in phagocytosis. Located in Golgi apparatus; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9BWL3|C1orf43
     1  MASGSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV GHNAPKDLKE
    61  EIDIRLSRVQ DIKYEPQLLA DDDARLLQLE TQGNQSCYNY LYRMKALDAI RTSEIPFHSE
   121  GRHPRSLMGK NFRSYLLDLR NTSTPFKGVR KALIDTLLDG YETARYGTGV FGQNEYLRYQ
   181  EALSELATAV KARIGSSQRH HQSAAKDLTQ SPEVSPTTIQ VTYLPSSQKS KRAKHFLELK
   241  SFKDNYNTLE STL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
448 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 448 nTPM
  • tongue: 344 nTPM
  • liver: 208 nTPM
  • kidney: 175 nTPM
  • choroid plexus: 174 nTPM
  • heart muscle: 168 nTPM

Single-cell type

  • esophageal apical cells: 380 nCPM
  • early spermatids: 326 nCPM
  • gastric progenitor cells: 308 nCPM
  • esophageal suprabasal cells: 287 nCPM
  • parietal cells: 278 nCPM
  • late spermatids: 269 nCPM

Immune cell

  • total PBMC: 243 nTPM
  • myeloid DC: 212 nTPM
  • classical monocyte: 205 nTPM
  • basophil: 192 nTPM
  • intermediate monocyte: 186 nTPM
  • non-classical monocyte: 175 nTPM

Brain region

  • white matter: 151 nTPM
  • basal ganglia: 134 nTPM
  • cerebellum: 134 nTPM
  • hypothalamus: 133 nTPM
  • thalamus: 127 nTPM
  • medulla oblongata: 124 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.21
DepMap dependency class
selective

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Lipid transport auxiliary protein 1
  • NICE-3 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf43 as an antibody target. Whether an autoantibody or antibody against C1orf43 could matter depends on whether native C1orf43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf43 is annotated at the cell surface, where native C1orf43 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C1orf43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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