Seroatlas · Human Serome Atlas

C1orf232

Uncharacterized protein C1orf232

Also known as: CA232_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RR37
Gene
C1orf232
Ensembl
ENSG00000282872
Chromosome
1
Canonical length
186 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C1orf232 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>A0A0U1RR37|C1orf232
     1  MNQAFWKTYK SKVLQTLSGE SEEDLAEERE NPALVGSETA EPTEETFNPM SQLARRVQGV
    61  GVKGWLTMSS LFNKEDEDKL LPSEPCADHP LAARPPSQAA AAAEARGPGF WDAFASRWQQ
   121  QQAAAASMLR GTEPTPEPDP EPADEAAEEA AERPESQEAE PVAGFKWGFL THKLAEMRVK
   181  AAPKGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf232 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 0.7 nTPM
  • thymus: 0.7 nTPM
  • pituitary gland: 0.3 nTPM
  • hypothalamus: 0.2 nTPM
  • retina: 0.2 nTPM
  • testis: 0.2 nTPM

Single-cell type

  • epididymal principal cells: 6.1 nCPM
  • oocytes: 4.6 nCPM
  • retinal amacrine cells: 3.9 nCPM
  • müller glia: 3.5 nCPM
  • retinal bipolar cells: 2 nCPM
  • late spermatids: 1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 1 nTPM
  • basal ganglia: 0.6 nTPM
  • cerebellum: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • midbrain: 0.4 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf232 as an antibody target. Whether an autoantibody or antibody against C1orf232 could matter depends on whether native C1orf232 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf232 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf232 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf232. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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