Seroatlas · Human Serome Atlas

C1orf226

Uncharacterized protein C1orf226

Also known as: CA226_HUMAN, FLJ13137

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L170
Gene: C1orf226
Ensembl: ENSG00000239887
Chromosome: 1
Canonical length: 272 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for C1orf226 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>A1L170|C1orf226
     1  MFENLNTALT PKLQASRSFP HLSKPVAPGS APLGSGEPGG PGLWVGSSQH LKNLGKAMGA
    61  KVNDFLRRKE PSSLGSVGVT EINKTAGAQL ASGTDAAPEA WLEDERSVLQ ETFPRLDPPP
   121  PITRKRTPRA LKTTQDMLIS SQPVLSSLEY GTEPSPGQAQ DSAPTAQPDV PADASQPEAT
   181  MEREERGKVL PNGEVSLSVP DLIHKDSQDE SKLKMTECRR ASSPSLIERN GFKLSLSPIS
   241  LAESWEDGSP PPQARTSSLD NEGPHPDLLS FE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf226 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

liver: 21 nTPM
kidney: 9.4 nTPM
pituitary gland: 9.4 nTPM
adrenal gland: 9.1 nTPM
rectum: 9.1 nTPM
colon: 8.7 nTPM

Single-cell type

late spermatids: 62 nCPM
hepatocytes: 32 nCPM
adrenal medulla cells: 32 nCPM
early spermatids: 29 nCPM
bergmann glia: 27 nCPM
goblet cells: 16 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 14 nTPM
white matter: 14 nTPM
spinal cord: 11 nTPM
hypothalamus: 9.7 nTPM
choroid plexus: 9.5 nTPM
cerebellum: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4628
Domain of unknown function (DUF4628)

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of C1orf226 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PLK1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf226 as an antibody target. Whether an autoantibody or antibody against C1orf226 could matter depends on whether native C1orf226 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf226 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf226 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...