Seroatlas · Human Serome Atlas

C1orf220

Putative uncharacterized protein C1orf220

Also known as: CA220_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T0J3
Gene
C1orf220
Canonical length
134 aa

OverviewNCBI Gene

No narrative summary is available for C1orf220 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q5T0J3|C1orf220
     1  MIPVRGLWYC YLQVKKVRLR EAERLGPKSQ CPAECGAASW ISWVLQHQQL LASEWATKDG
    61  RGTWGSKPSC TVPALSATSQ LLQLGRLNSD LQFVRQRAKK SVSSPSLLQF WCCLSRLSFH
   121  ALNQKINSTN INIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf220 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0.24
gnomAD missense Z
0.78

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF5576
  • Family of unknown function (DUF5576)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf220 as an antibody target. Whether an autoantibody or antibody against C1orf220 could matter depends on whether native C1orf220 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf220 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf220 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf220. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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