C1orf216
UPF0500 protein C1orf216
Also known as: CA216_HUMAN, FLJ38984
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TAB5
- Gene
- C1orf216
- Ensembl
- ENSG00000142686
- Chromosome
- 1
- Canonical length
- 229 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for C1orf216 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
229 residues, UniProt reviewed canonical sequence.
>Q8TAB5|C1orf216
1 MFAIQPGLAE GGQFLGDPPP GLCQPELQPD SNSNFMASAK DANENWHGMP GRVEPILRRS
61 SSESPSDNQA FQAPGSPEEG VRSPPEGAEI PGAEPEKMGG AGTVCSPLED NGYASSSLSI
121 DSRSSSPEPA CGTPRGPGPP DPLLPSVAQA VQHLQVQERY KEQEKEKHHV HLVMYRRLAL
181 LQWIRGLQHQ LIDQQARLQE SFDTILDNRK ELIRCLQQRA APSRPQDQALocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1orf216 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 76 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 76 nTPM
- amygdala: 49 nTPM
- hippocampal formation: 49 nTPM
- basal ganglia: 41 nTPM
- hypothalamus: 39 nTPM
- midbrain: 28 nTPM
Single-cell type
- late primary spermatocytes: 25 nCPM
- retinal horizontal cells: 22 nCPM
- other brain neurons: 20 nCPM
- hepatic stellate cells: 19 nCPM
- brain excitatory neurons: 19 nCPM
- retinal amacrine cells: 19 nCPM
Immune cell
- memory CD8 T-cell: 5.3 nTPM
- gdT-cell: 4.3 nTPM
- memory CD4 T-cell: 3.4 nTPM
- naive CD8 T-cell: 3.1 nTPM
- total PBMC: 2.9 nTPM
- intermediate monocyte: 2.8 nTPM
Brain region
- cerebral cortex: 76 nTPM
- hippocampal formation: 65 nTPM
- basal ganglia: 56 nTPM
- hypothalamus: 55 nTPM
- white matter: 55 nTPM
- pons: 46 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4653
- Domain of unknown function (DUF4653)
InteractionsUniProt · HPA
Protein binding partners of C1orf216 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1orf216 as an antibody target. Whether an autoantibody or antibody against C1orf216 could matter depends on whether native C1orf216 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1orf216 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C1orf216 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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