Seroatlas · Human Serome Atlas

C1orf210

Type III endosome membrane protein TEMP

Also known as: CA210_HUMAN, MGC52423, TEMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVY1
Gene
C1orf210
Ensembl
ENSG00000253313
Chromosome
1
Canonical length
113 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to be located in early endosome; plasma membrane; and recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q8IVY1|C1orf210
     1  MNETNKTLVG PSELPTASAV APGPGTGARA WPVLVGFVLG AVVLSLLIAL AAKCHLCRRY
    61  HASYRHRPLP ETGRGGRPQV AEDEDDDGFI EDNYIQPGTG ELGTEGSRDH FSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf210 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 41 nTPM
  • small intestine: 37 nTPM
  • colon: 30 nTPM
  • rectum: 28 nTPM
  • stomach: 27 nTPM
  • pancreas: 22 nTPM

Single-cell type

  • esophageal apical cells: 160 nCPM
  • enterocytes: 121 nCPM
  • colonocytes: 107 nCPM
  • breast lactating cells: 92 nCPM
  • parietal cells: 57 nCPM
  • esophageal suprabasal cells: 50 nCPM

Immune cell

  • basophil: 2.2 nTPM
  • myeloid DC: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • white matter: 2.5 nTPM
  • cerebellum: 2.4 nTPM
  • cerebral cortex: 1.9 nTPM
  • midbrain: 1.7 nTPM
  • pons: 1.7 nTPM
  • choroid plexus: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf210 as an antibody target. Whether an autoantibody or antibody against C1orf210 could matter depends on whether native C1orf210 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf210 is annotated at the cell surface, where native C1orf210 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C1orf210 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf210. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...