C1orf21
Uncharacterized protein C1orf21
Also known as: CA021_HUMAN, PIG13
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H246
- Gene
- C1orf21
- Ensembl
- ENSG00000116667
- Chromosome
- 1
- Canonical length
- 121 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for C1orf21 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
121 residues, UniProt reviewed canonical sequence.
>Q9H246|C1orf21
1 MGCASAKHVA TVQNEEEAQK GKNYQNGDVF GDEYRIKPVE EVKYMKNGAE EEQKIAARNQ
61 ENLEKSASSN VRLKTNKEVP GLVHQPRANM HISESQQEFF RMLDEKIEKG RDYCSEEEDI
121 TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1orf21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 36 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 36 nTPM
- tongue: 19 nTPM
- cerebral cortex: 18 nTPM
- cerebellum: 15 nTPM
- amygdala: 14 nTPM
- skin: 13 nTPM
Single-cell type
- myonuclei: 1,766 nCPM
- pituicytes/fscs: 727 nCPM
- basal prostatic cells: 618 nCPM
- syncytiotrophoblasts: 616 nCPM
- fibro-adipogenic progenitors: 534 nCPM
- oligodendrocyte progenitor cells: 530 nCPM
Immune cell
- gdT-cell: 3.9 nTPM
- NK-cell: 2.6 nTPM
- memory CD8 T-cell: 2 nTPM
- naive CD8 T-cell: 1.8 nTPM
- total PBMC: 0.9 nTPM
- memory CD4 T-cell: 0.5 nTPM
Brain region
- cerebral cortex: 37 nTPM
- basal ganglia: 36 nTPM
- hippocampal formation: 32 nTPM
- cerebellum: 29 nTPM
- pons: 28 nTPM
- medulla oblongata: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.41
- gnomAD pLI
- 0.89
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4612
- Domain of unknown function (DUF4612)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C1orf21 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1orf21 as an antibody target. Whether an autoantibody or antibody against C1orf21 could matter depends on whether native C1orf21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1orf21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C1orf21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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