Seroatlas · Human Serome Atlas

C1orf198

Uncharacterized protein C1orf198

Also known as: CA198_HUMAN, DKFZp667D152, FLJ14525, FLJ16283, FLJ38847, MGC10710

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H425
Gene: C1orf198
Ensembl: ENSG00000119280
Chromosome: 1
Canonical length: 327 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q9H425|C1orf198
     1  MASMAAAIAA SRSAVMSGNR PLDDRERKRF TYFSSLSPMA RKIMQDKEKI REKYGPEWAR
    61  LPPAQQDEII DRCLVGPRAP APRDPGDSEE LTRFPGLRGP TGQKVVRFGD EDLTWQDEHS
   121  APFSWETKSQ MEFSISALSI QEPSNGTAAS EPRPLSKASQ GSQALKSSQG SRSSSLDALG
   181  PTRKEEEASF WKINAERSRG EGPEAEFQSL TPSQIKSMEK GEKVLPPCYR QEPAPKDREA
   241  KVERPSTLRQ EQRPLPNVST ERERPQPVQA FSSALHEAAP SQLEGKLPSP DVRQDDGEDT
   301  LFSEPKFAQV SSSNVVLKTG FDFLDNW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf198 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 144 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 144 nTPM
blood vessel: 106 nTPM
skeletal muscle: 104 nTPM
midbrain: 82 nTPM
hippocampal formation: 65 nTPM
lung: 63 nTPM

Single-cell type

platelets: 168 nCPM
alveolar cells type 1: 143 nCPM
ependymal cells: 140 nCPM
schwann cells: 112 nCPM
thymic myoid cells: 110 nCPM
hepatic stellate cells: 103 nCPM

Immune cell

basophil: 13 nTPM
total PBMC: 4.7 nTPM
NK-cell: 3 nTPM
intermediate monocyte: 2.7 nTPM
naive CD4 T-cell: 2.6 nTPM
MAIT T-cell: 2.4 nTPM

Brain region

white matter: 207 nTPM
medulla oblongata: 171 nTPM
midbrain: 161 nTPM
basal ganglia: 161 nTPM
spinal cord: 149 nTPM
thalamus: 139 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4706
Domain of unknown function (DUF4706)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf198 as an antibody target. Whether an autoantibody or antibody against C1orf198 could matter depends on whether native C1orf198 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf198 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf198 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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