Seroatlas · Human Serome Atlas

C1orf185

Uncharacterized protein C1orf185

Also known as: CA185_HUMAN, FLJ27485

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T7R7
Gene
C1orf185
Ensembl
ENSG00000204006
Chromosome
1
Canonical length
199 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q5T7R7|C1orf185
     1  MASPKGFFNY LTYFLAAGAV TLGIGFFALA SALWFLICKR REIFQNSKFK AIDERCRQRP
    61  SMAKIKSHSQ CVFISRNFHT GRFQLQEEQR KKEAAHIKAI KDHSKDEPQL ATKNIICDPS
   121  ETSSTTNRSS VTLSLSTLPS DSYYSQSIEA ADDWFSDDSL VKRNSPMPSL GEPLMEKVFS
   181  YLSTISLEEG TESVLNDTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf185 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • testis: 24 nTPM
  • adipose tissue: 0.1 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 674 nCPM
  • late primary spermatocytes: 420 nCPM
  • late spermatids: 54 nCPM
  • adipocytes: 7.5 nCPM
  • oligodendrocyte progenitor cells: 6.7 nCPM
  • pituicytes/fscs: 6.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
1.09
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4718
  • Domain of unknown function (DUF4718)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf185 as an antibody target. Whether an autoantibody or antibody against C1orf185 could matter depends on whether native C1orf185 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf185 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf185 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf185. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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