Seroatlas · Human Serome Atlas

C1orf167

Uncharacterized protein C1orf167

Also known as: CA167_HUMAN, DKFZp434E1410, RP11-56N19.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SNV9
Gene: C1orf167
Ensembl: ENSG00000215910
Chromosome: 1
Canonical length: 1449 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Implicated in coronary artery disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1449 residues, UniProt reviewed canonical sequence.

>Q5SNV9|C1orf167
     1  MELRSDASHK ENVSPKPAAL PKPEQRRFRR SLGIGLSGRH DQWVPGCQVE RGGPAATPSP
    61  GAVLDQEPCR VQTNLASPGP RLGLALKDTT GQLVNSSFWQ QSNLQSLARR RQGKAREFAI
   121  QQSNLSINET SSPHLCPEPG GSSGPHKLPW GPLLSQEPLA RPSSCLRQSG LPAPGTPSGD
   181  FRPTEAFAPL DGHTQPGLRS WGGLGSWRSR LVGEPLTLED LAVPSQNQTQ APSRAAVHQL
   241  LASVHCLAQE AARLRCQAPQ EPPGAVQQDL WTGGGQPFSA HPQPSQPVLA SSDGRRRRLR
   301  GHRETAAFLE TPASLSDSWA QSKLMSPETT LGTRTKDSLN PEQGLPPAHP LGSGDSCSPW
   361  SQDGRAQRGD PSLPRGVGSR GTDPCSSAFS NTAWGVSPKQ KGEEGAPRER VHREEERTAF
   421  HLSDTVPASS ASKNKAQNIT APESEAICWQ LLSRCFRSWR HLVKRQREPA AAAVALGRWQ
   481  LLRKCLQALW LREAQLEAAW GQYTKVLLVR SFREWRNLAL QQKQVQPHMQ AGPGSPPSRR
   541  AQGKGLSLGR STVVDPAQRS RLEHTSPGSL REEEIAQRLL SHPRQRTDSR HERVQILQAL
   601  QLAVFFLWCQ QKKRARQERE TLRKATRATQ RTGSFPQAWH STAAGVAWVA PLSPQHQRAW
   661  LCRCFGAWQQ FVQRGSRYRD HLADRRTGTL RKCLEQWVRM KQLRESDGAK VTQLSLCRQK
   721  AGREAVYTAG PGACGLGAVG QAQGQQEQGR GSLQDACWTL ALCWALLLWK MRLFQRQWAN
   781  SFFQGLQQRM LQRSLRWWHL RALGPDATSS CTKTPSALEP LSSSTLQDSL EKVPRAPTLP
   841  DTLQGSLLWA AGQRQQGQCL LLWQARAQQF QGTARWYQHT RQRRIFLSWS RWATAQWAWR
   901  ELASHRAWDR TCRAVLGLWR QRLLQSRLVE WWAQERGWRL ARDALCHWHS CWQGQQFLHE
   961  KCQTWVQVHL QGLQKVVFRS WQQAAAHQRC TVTRPEQLLL QSYFQAWCEV VRDTGVLRAQ
  1021  HQAFQDGLRR RALGAVFATW REAQEVAAGA QEQRVAQASL ARWRSCGQQG QEDGQQKKAR
  1081  APQAFPAWPV APGMHHEAQQ QAGESAGAQA AQCWTWCWAL WVHESCRGQV SRAHASWKPR
  1141  AWVLEASVQS AVRGGVQRAI LTQLRPAELR RFLRTVQLRV RLGLPGAGKT RSCWTQATEL
  1201  VPPAPSLQCS LGGRRKPRGT AWAQRCREHS LCPAFQLWPQ WPGQSSWVPG LPLWTRDQGP
  1261  RAHSSPEPRA CKAQSKAHKR RLRARSCRIL EKQAQAHGSA LLLALKGHDA LGHQEEVPAA
  1321  PVPRGTASRA AGFPAGQVPG SGMAALGGCP RGRAAGADPA QGVAPEMGLA DVVAADPATA
  1381  SGSAVTAAGR WAFKKWHQRL AARSPRRGAA SSPRPWSKPG PKGPESGQEA ARAPRGWGLG
  1441  AEHGAQLQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf167 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
lung: 0.5 nTPM
skeletal muscle: 0.5 nTPM
heart muscle: 0.3 nTPM
spleen: 0.3 nTPM
adipose tissue: 0.2 nTPM

Single-cell type

cardiomyocytes: 100 nCPM
alveolar cells type 1: 80 nCPM
oocytes: 69 nCPM
epicardial cells: 66 nCPM
late primary spermatocytes: 39 nCPM
alveolar cells type 2: 36 nCPM

Immune cell

memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 0.4 nTPM
cerebral cortex: 0.4 nTPM
spinal cord: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 1.12

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4684
Domain of unknown function (DUF4684)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf167 as an antibody target. Whether an autoantibody or antibody against C1orf167 could matter depends on whether native C1orf167 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf167 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf167 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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