Seroatlas · Human Serome Atlas

C1orf162

Transmembrane protein C1orf162

Also known as: CA162_HUMAN, MGC24133

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEQ5
Gene
C1orf162
Ensembl
ENSG00000143110
Chromosome
1
Canonical length
155 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q8NEQ5|C1orf162
     1  MGGNGSTCKP DTERQGTLST AAPTTSPAPC LSNHHNKKHL ILAFCAGVLL TLLLIAFIFL
    61  IIKSYRKYRR ERLPISPGPL LRWVPLLSGT MADHSKPQAP DPHSDPPAKL SSIPGESLTY
   121  ASTTFKLSEE KSNHLAENHS ADFDPIVYAQ IKVTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf162 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
151 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 151 nTPM
  • bone marrow: 109 nTPM
  • lung: 81 nTPM
  • choroid plexus: 70 nTPM
  • appendix: 67 nTPM
  • lymph node: 66 nTPM

Single-cell type

  • kupffer cells: 867 nCPM
  • monocytes: 532 nCPM
  • neutrophils: 472 nCPM
  • cdc: 418 nCPM
  • macrophages: 338 nCPM
  • monocyte progenitors: 210 nCPM

Immune cell

  • intermediate monocyte: 1,532 nTPM
  • eosinophil: 1,298 nTPM
  • total PBMC: 1,190 nTPM
  • non-classical monocyte: 1,179 nTPM
  • basophil: 1,119 nTPM
  • classical monocyte: 1,029 nTPM

Brain region

  • thalamus: 23 nTPM
  • white matter: 17 nTPM
  • medulla oblongata: 16 nTPM
  • pons: 14 nTPM
  • choroid plexus: 14 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein C1orf162

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf162 as an antibody target. Whether an autoantibody or antibody against C1orf162 could matter depends on whether native C1orf162 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf162 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf162 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf162. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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