Seroatlas · Human Serome Atlas

C1orf159

Uncharacterized protein C1orf159

Also known as: CA159_HUMAN, FLJ20584

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HA4
Gene: C1orf159
Ensembl: ENSG00000131591
Chromosome: 1
Canonical length: 380 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli rim,Mitotic chromosome,Intermediate filaments

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q96HA4|C1orf159
     1  MALRHLALLA GLLVGVASKS MENTVTRNST AVINTQAEGT LSPPGLSSLP VVREWALTHT
    61  AQLPECCVDV VGVNASCPGA SLCGPGCYRR WNADGSASCV RCGNGTLPAY NGSECRSFAG
   121  PGAPFPMNRS SGTPGRPHPG APRVAASLFL GTFFISSGLI LSVAGFFYLK RSSKLPRACY
   181  RRNKAPALQP GEAAAMIPPP QSSGNSSCRI PLWGFPSLGQ SQGALWVCPQ TGLPGSGSRP
   241  PLPGSPGDPP TRQGQGRIWL VPPALDLSWI WPAPPARPPL IPVTSMLFPV PETWGLQERR
   301  THHDRADPQY LLLLEVQLHP RTDAAGLRQA LLSSHRFSGA GSGGPKSQPV RKPRYVRRER
   361  PLDRATDPAA FPGEARISNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf159 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
cerebral cortex: 12 nTPM
hippocampal formation: 11 nTPM
amygdala: 10 nTPM
basal ganglia: 9.9 nTPM
cerebellum: 8.6 nTPM

Single-cell type

late spermatids: 228 nCPM
early spermatids: 73 nCPM
late primary spermatocytes: 66 nCPM
ependymal cells: 62 nCPM
esophageal apical cells: 51 nCPM
urothelial cells: 51 nCPM

Immune cell

basophil: 8.1 nTPM
memory CD8 T-cell: 3 nTPM
MAIT T-cell: 2.8 nTPM
NK-cell: 2.7 nTPM
classical monocyte: 2.6 nTPM
gdT-cell: 2.6 nTPM

Brain region

cerebral cortex: 50 nTPM
amygdala: 48 nTPM
hippocampal formation: 44 nTPM
basal ganglia: 43 nTPM
medulla oblongata: 42 nTPM
white matter: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4501
Domain of unknown function (DUF4501)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf159 as an antibody target. Whether an autoantibody or antibody against C1orf159 could matter depends on whether native C1orf159 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf159 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf159 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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