C1orf141
Uncharacterized protein C1orf141
Also known as: CA141_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5JVX7
- Gene
- C1orf141
- Ensembl
- ENSG00000203963
- Chromosome
- 1
- Canonical length
- 400 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Intermediate filaments
OverviewNCBI Gene
No narrative summary is available for C1orf141 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
400 residues, UniProt reviewed canonical sequence.
>Q5JVX7|C1orf141
1 MAEKILEKLD VLDKQAEIIL ARRTKINRLQ SEGRKTTMAI PLTFDFQLEF EEALATSASK
61 AISKIKEDKS CSITKSKMHV SFKCEPEPRK SNFEKSNLRP FFIQTNVKNK ESESTAQIEK
121 KPRKPLDSVG LLEGDRNKRK KSPQMNDFNI KENKSVRNYQ LSKYRSVRKK SLLPLCFEDE
181 LKNPHAKIVN VSPTKTVTSH MEQKDTNPII FHDTEYVRML LLTKNRFSSH PLENENIYPH
241 KRTNFILERN CEILKSIIGN QSISLFKPQK TMPTVQRKDI QIPMSFKAGH TTVDDKLKKK
301 TNKQTLENRS WNTLYNFSQN FSSLTKQFVG YLDKAVIHEM SAQTGKFERM FSAGKPTSIP
361 TSSALPVKCY SKPFKYIYEL NNVTPLDNLL NLSNEILNASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1orf141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- testis: 14 nTPM
- fallopian tube: 8.7 nTPM
- retina: 3 nTPM
- choroid plexus: 2.6 nTPM
- lung: 1 nTPM
- basal ganglia: 0.5 nTPM
Single-cell type
- late spermatids: 135 nCPM
- late primary spermatocytes: 111 nCPM
- early spermatids: 107 nCPM
- fallopian tube ciliated cells: 96 nCPM
- granulosa cells: 88 nCPM
- sertoli cells: 88 nCPM
Immune cell
- basophil: 0.5 nTPM
- neutrophil: 0.2 nTPM
- NK-cell: 0.2 nTPM
- total PBMC: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- choroid plexus: 5.1 nTPM
- medulla oblongata: 2.2 nTPM
- spinal cord: 1.8 nTPM
- midbrain: 1.6 nTPM
- hypothalamus: 0.9 nTPM
- white matter: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.05
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4545
- Domain of unknown function (DUF4545)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1orf141 as an antibody target. Whether an autoantibody or antibody against C1orf141 could matter depends on whether native C1orf141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1orf141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C1orf141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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