Seroatlas · Human Serome Atlas

C1orf140

Putative uncharacterized protein C1orf140

Also known as: CA140_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VVS0
Gene: C1orf140
Canonical length: 124 aa

OverviewNCBI Gene

No narrative summary is available for C1orf140 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q5VVS0|C1orf140
     1  MTQNSSSLGD RIITPYTPPR SQPMNKHLFV SLSTLFQTTE LDFANKKSCF LCLPLRADGF
    61  PEMPHSPAQT ERMQKLAKDP PHARSEDVPD HLFFVDTAGL REIVCFCGVL SLRTSEGLMR
   121  KETA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf140 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf140 as an antibody target. Whether an autoantibody or antibody against C1orf140 could matter depends on whether native C1orf140 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf140 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf140 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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