Seroatlas · Human Serome Atlas

C1orf115

Required for drug-induced death protein 1

Also known as: FLJ14146, RDD1, RDD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7X2
Gene: C1orf115
Ensembl: ENSG00000162817
Chromosome: 1
Canonical length: 142 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in regulation of response to drug. Located in 9+0 non-motile cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q9H7X2|C1orf115
     1  MTVGARLRSK AESSLLRRGP RGRGRTEGDE EAAAILEHLE YADEAEAAAE SGTSAADERG
    61  PGTRGARRVH FALLPERYEP LEEPAPSEQP RKRYRRKLKK YGKNVGKVII KGCRYVVIGL
   121  QGFAAAYSAP FAVATSVVSF VR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf115 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

small intestine: 114 nTPM
duodenum: 106 nTPM
liver: 98 nTPM
cerebral cortex: 88 nTPM
salivary gland: 70 nTPM
placenta: 66 nTPM

Single-cell type

enterocytes: 252 nCPM
syncytiotrophoblasts: 246 nCPM
hepatocytes: 136 nCPM
parietal cells: 120 nCPM
extravillous trophoblasts: 110 nCPM
migrating cytotrophoblasts: 89 nCPM

Immune cell

naive B-cell: 1 nTPM
memory B-cell: 0.5 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 88 nTPM
basal ganglia: 79 nTPM
amygdala: 49 nTPM
white matter: 41 nTPM
hippocampal formation: 39 nTPM
choroid plexus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0.04
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of response to drug

Cellular components

Protein domainsUniProt · Pfam · InterPro

Required for drug-induced death protein 1
Required for drug-induced death protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf115 as an antibody target. Whether an autoantibody or antibody against C1orf115 could matter depends on whether native C1orf115 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf115 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf115 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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