Seroatlas · Human Serome Atlas

C1orf105

Uncharacterized protein C1orf105

Also known as: CA105_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95561
Gene
C1orf105
Ensembl
ENSG00000180999
Chromosome
1
Canonical length
183 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

No narrative summary is available for C1orf105 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>O95561|C1orf105
     1  MEKRELKASV PKFDKIPWLS EASLVNKPLV LSLPRRYPHT SATFLTSSKK NMNLPILFQV
    61  PDVLSKARRN QCDSMLLRNQ QLCSTCQEMK MVQPRTMKIP DDPKASFENC MSYRMSLHQP
   121  KFQTTPEPFH DDIPTESIHY RLPILGPRTA VFHGLLTEAY KTLKERQRSS LPRKEPIGKT
   181  TRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf105 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • testis: 25 nTPM
  • heart muscle: 17 nTPM
  • epididymis: 5.1 nTPM
  • tongue: 3.1 nTPM
  • bone marrow: 1.8 nTPM
  • skeletal muscle: 1.3 nTPM

Single-cell type

  • late primary spermatocytes: 269 nCPM
  • early spermatids: 151 nCPM
  • cardiomyocytes: 87 nCPM
  • epicardial cells: 34 nCPM
  • migrating cytotrophoblasts: 32 nCPM
  • adipocytes: 21 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 6.2 nTPM
  • white matter: 5.3 nTPM
  • medulla oblongata: 4.7 nTPM
  • pons: 4.6 nTPM
  • basal ganglia: 4.5 nTPM
  • cerebral cortex: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4548
  • Domain of unknown function (DUF4548)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf105 as an antibody target. Whether an autoantibody or antibody against C1orf105 could matter depends on whether native C1orf105 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf105 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf105 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1orf105. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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