Seroatlas · Human Serome Atlas

C1RL

Complement C1r subcomponent-like protein

Also known as: C1r-LP, C1RL_HUMAN, C1RL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZP8
Gene: C1RL
Ensembl: ENSG00000139178
Chromosome: 12
Canonical length: 487 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q9NZP8|C1RL
     1  MPGPRVWGKY LWRSPHSKGC PGAMWWLLLW GVLQACPTRG SVLLAQELPQ QLTSPGYPEP
    61  YGKGQESSTD IKAPEGFAVR LVFQDFDLEP SQDCAGDSVT ISFVGSDPSQ FCGQQGSPLG
   121  RPPGQREFVS SGRSLRLTFR TQPSSENKTA HLHKGFLALY QTVAVNYSQP ISEASRGSEA
   181  INAPGDNPAK VQNHCQEPYY QAAAAGALTC ATPGTWKDRQ DGEEVLQCMP VCGRPVTPIA
   241  QNQTTLGSSR AKLGNFPWQA FTSIHGRGGG ALLGDRWILT AAHTIYPKDS VSLRKNQSVN
   301  VFLGHTAIDE MLKLGNHPVH RVVVHPDYRQ NESHNFSGDI ALLELQHSIP LGPNVLPVCL
   361  PDNETLYRSG LLGYVSGFGM EMGWLTTELK YSRLPVAPRE ACNAWLQKRQ RPEVFSDNMF
   421  CVGDETQRHS VCQGDSGSVY VVWDNHAHHW VATGIVSWGI GCGEGYDFYT KVLSYVDWIK
   481  GVMNGKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1RL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 134 nTPM

Expression across tissuesHPA

Tissue

liver: 134 nTPM
adrenal gland: 69 nTPM
ovary: 48 nTPM
blood vessel: 38 nTPM
urinary bladder: 37 nTPM
adipose tissue: 37 nTPM

Single-cell type

proximal tubule cells: 47 nCPM
papillary tip epithelial cells: 45 nCPM
renal collecting duct principal cells: 42 nCPM
loop of henle epithelial cells: 40 nCPM
podocytes: 35 nCPM
distal convoluted tubule cells: 34 nCPM

Immune cell

neutrophil: 5.4 nTPM
eosinophil: 4 nTPM
basophil: 3.8 nTPM
non-classical monocyte: 1.3 nTPM
memory B-cell: 1.2 nTPM
intermediate monocyte: 1.1 nTPM

Brain region

medulla oblongata: 15 nTPM
choroid plexus: 14 nTPM
midbrain: 9.6 nTPM
hypothalamus: 7.8 nTPM
thalamus: 7.7 nTPM
pons: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1RL as an antibody target. Whether an autoantibody or antibody against C1RL could matter depends on whether native C1RL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1RL is annotated as secreted, so native C1RL circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1RL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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