Seroatlas · Human Serome Atlas

C1QTNF4

Complement C1q tumor necrosis factor-related protein 4

Also known as: C1QT4_HUMAN, CTRP4, ZACRP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXJ3
Gene: C1QTNF4
Ensembl: ENSG00000172247
Chromosome: 11
Canonical length: 329 aa
Protein class: Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Secreted in brain
Quaternary structure: Homomultimer

OverviewNCBI Gene

Predicted to enable cytokine activity. Involved in positive regulation of cytokine production and positive regulation of signal transduction. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9BXJ3|C1QTNF4
     1  MLPLLLGLLG PAACWALGPT PGPGSSELRS AFSAARTTPL EGTSEMAVTF DKVYVNIGGD
    61  FDVATGQFRC RVPGAYFFSF TAGKAPHKSL SVMLVRNRDE VQALAFDEQR RPGARRAASQ
   121  SAMLQLDYGD TVWLRLHGAP QYALGAPGAT FSGYLVYADA DADAPARGPP APPEPRSAFS
   181  AARTRSLVGS DAGPGPRHQP LAFDTEFVNI GGDFDAAAGV FRCRLPGAYF FSFTLGKLPR
   241  KTLSVKLMKN RDEVQAMIYD DGASRRREMQ SQSVMLALRR GDAVWLLSHD HDGYGAYSNH
   301  GKYITFSGFL VYPDLAPAAP PGLGASELL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 130 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 130 nTPM
cerebral cortex: 62 nTPM
amygdala: 47 nTPM
cerebellum: 44 nTPM
hippocampal formation: 42 nTPM
midbrain: 35 nTPM

Single-cell type

astrocytes: 48 nCPM
brain inhibitory neurons: 47 nCPM
other brain neurons: 31 nCPM
brain excitatory neurons: 28 nCPM
bergmann glia: 20 nCPM
oligodendrocytes: 9.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 101 nTPM
cerebellum: 59 nTPM
cerebral cortex: 58 nTPM
amygdala: 48 nTPM
thalamus: 47 nTPM
hippocampal formation: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.17
gnomAD missense Z: 1.65
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF4 as an antibody target. Whether an autoantibody or antibody against C1QTNF4 could matter depends on whether native C1QTNF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF4 is annotated as secreted, so native C1QTNF4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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