Seroatlas · Human Serome Atlas

C1QTNF12

Adipolin

Also known as: ADIPL_HUMAN, ADIPOLIN, C1QDC2, CTRP12, FAM132A, MGC105127

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T7M4
Gene
C1QTNF12
Ensembl
ENSG00000184163
Chromosome
1
Canonical length
302 aa
Protein class
Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood
Quaternary structure
Homomultimer

OverviewNCBI Gene

Predicted to enable hormone activity. Predicted to be involved in negative regulation of gluconeogenesis; positive regulation of D-glucose import; and positive regulation of insulin receptor signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response; positive regulation of cell communication; and regulation of glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>Q5T7M4|C1QTNF12
     1  MRRWAWAAVV VLLGPQLVLL GGVGARREAQ RTQQPGQRAD PPNATASASS REGLPEAPKP
    61  SQASGPEFSD AHMTWLNFVR RPDDGALRKR CGSRDKKPRD LFGPPGPPGA EVTAETLLHE
   121  FQELLKEATE RRFSGLLDPL LPQGAGLRLV GEAFHCRLQG PRRVDKRTLV ELHGFQAPAA
   181  QGAFLRGSGL SLASGRFTAP VSGIFQFSAS LHVDHSELQG KARLRARDVV CVLICIESLC
   241  QRHTCLEAVS GLESNSRVFT LQVQGLLQLQ AGQYASVFVD NGSGAVLTIQ AGSSFSGLLL
   301  GT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 6.4 nTPM
  • small intestine: 6.3 nTPM
  • skin: 6.2 nTPM
  • kidney: 3.5 nTPM
  • colon: 3.2 nTPM
  • testis: 2.4 nTPM

Single-cell type

  • enterocytes: 210 nCPM
  • colonocytes: 124 nCPM
  • extravillous trophoblasts: 20 nCPM
  • foveolar cells: 19 nCPM
  • gastric progenitor cells: 15 nCPM
  • goblet cells: 15 nCPM

Immune cell

  • NK-cell: 0.6 nTPM
  • neutrophil: 0.5 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 2.1 nTPM
  • medulla oblongata: 2 nTPM
  • cerebral cortex: 1.5 nTPM
  • pons: 1.5 nTPM
  • thalamus: 1.4 nTPM
  • white matter: 1.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C1QTNF12.

Disease | ImmuneIEDB

Conditions an epitope on C1QTNF12 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF12 as an antibody target. Whether an autoantibody or antibody against C1QTNF12 could matter depends on whether native C1QTNF12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF12 is annotated as secreted, so native C1QTNF12 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1QTNF12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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