Seroatlas · Human Serome Atlas

C1GALT1C1L

C1GALT1-specific chaperone 1-like protein

Also known as: C1C1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DN25
Gene
C1GALT1C1L
Ensembl
ENSG00000223658
Chromosome
2
Canonical length
315 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>P0DN25|C1GALT1C1L
     1  MVSASGTSFF KGMLLGSISW VLITMFGQIH IRHRGQTQDH EHHHLRPPNR NDFLNTSKVI
    61  LLELSKSIRV FCIIFGESED ESYWAVLKET WTKHCDKAEL YDTKNDNLFN IESNDRWVQM
   121  RTAYKYVFEK YGDNYNWFFL ALPTTFAVIE NLKYLLFTRD ASQPFYLGHT VIFGDLEYVT
   181  VEGGIVLSRE LMKRLNRLLD NSETCADQSV IWKLSEDKQL AICLKYAGVH AENAEDYEGR
   241  DVFNTKPIAQ LIEEALSNNP QQVVEGCCSD MAITFNGLTP QKMEVMMYGL YRLRAFGHYF
   301  NDTLVFLPPV GSEND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1GALT1C1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
5.6 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 5.6 nTPM
  • testis: 5.5 nTPM
  • endometrium: 3.8 nTPM
  • retina: 3.6 nTPM
  • smooth muscle: 3 nTPM
  • cervix: 2.6 nTPM

Single-cell type

  • decidual stromal cells: 19 nCPM
  • late primary spermatocytes: 17 nCPM
  • early primary spermatocytes: 13 nCPM
  • epididymal principal cells: 6 nCPM
  • endometrial stromal cells: 5.4 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.5 nTPM
  • midbrain: 1.5 nTPM
  • basal ganglia: 1.4 nTPM
  • white matter: 1.4 nTPM
  • hypothalamus: 1.3 nTPM
  • medulla oblongata: 1.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1GALT1C1L as an antibody target. Whether an autoantibody or antibody against C1GALT1C1L could matter depends on whether native C1GALT1C1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1GALT1C1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1GALT1C1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1GALT1C1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...