Seroatlas · Human Serome Atlas

C19orf85

Uncharacterized protein C19orf85

Also known as: CS085_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUS0
Gene
C19orf85
Ensembl
ENSG00000283567
Chromosome
19
Canonical length
222 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C19orf85 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>A0A1B0GUS0|C19orf85
     1  MHPGVPEGPG VSEPGPRELC AFVSGAAAHM LRALQPRRTR PPKRRPNHRR FLHNQICRQF
    61  TKIEAATQRL ALSILSQEAP PQRPSLQKPP PPPPSPFLGV ACAVAPTEAP HASASLSLAA
   121  LDTSTLDLFD NIALTPECAS MPWDPSSGSD APLPAPGLSH RDLGQLDLRQ VPHFCGPLPL
   181  PQHALGEEAD LVAPDWGWVD CWEVPRAWDS QGIPEGWGTS SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C19orf85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • colon: 0.5 nTPM
  • hypothalamus: 0.1 nTPM
  • lung: 0.1 nTPM
  • seminal vesicle: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • cdc: 0.3 nCPM
  • pituicytes/fscs: 0.3 nCPM
  • submucosal glandular cells: 0.3 nCPM
  • endometrial ciliated cells: 0.2 nCPM
  • alveolar cells type 1: 0.1 nCPM
  • late primary spermatocytes: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.6 nTPM
  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C19orf85 as an antibody target. Whether an autoantibody or antibody against C19orf85 could matter depends on whether native C19orf85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C19orf85 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C19orf85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C19orf85. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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