Seroatlas · Human Serome Atlas

C19orf81

Putative uncharacterized protein C19orf81

Also known as: CS081_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9J6K1
Gene
C19orf81
Ensembl
ENSG00000235034
Chromosome
19
Canonical length
198 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Aggresome

OverviewNCBI Gene

No narrative summary is available for C19orf81 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>C9J6K1|C19orf81
     1  MQPEVEPVCF PAMGSPTMHR KAGALLMDLE TPEEMQARSL GRPIKSSKQY LRQVIAEYEA
    61  LDRELPCIRK FPTPPASQPL CLCMETLPEE DFTHLEVLQA LEAQLPGAME SGRVSSIRFE
   121  NMNVICGTAG RRNRWLIAVT DFQTRSRLLR SGLSPRGLAH QIVRHDDLLL GDYRLHLRRS
   181  LVRRRMLEAL GAEPNEEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C19orf81 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
6.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.7 nTPM
  • spinal cord: 0.5 nTPM
  • epididymis: 0.3 nTPM
  • parathyroid gland: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • midbrain: 0.2 nTPM

Single-cell type

  • epididymal principal cells: 114 nCPM
  • epididymal efferent duct absorptive cells: 73 nCPM
  • late primary spermatocytes: 42 nCPM
  • epididymal efferent duct ciliated cells: 35 nCPM
  • müller glia: 30 nCPM
  • epididymal clear cells: 29 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 5.5 nTPM
  • cerebral cortex: 2.6 nTPM
  • pons: 2.1 nTPM
  • white matter: 2.1 nTPM
  • hippocampal formation: 2 nTPM
  • medulla oblongata: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4732
  • Domain of unknown function (DUF4732)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C19orf81 as an antibody target. Whether an autoantibody or antibody against C19orf81 could matter depends on whether native C19orf81 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C19orf81 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C19orf81 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C19orf81. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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