C19orf73
Putative uncharacterized protein C19orf73
Also known as: CS073_HUMAN, FLJ10490
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NVV2
- Gene
- C19orf73
- Ensembl
- ENSG00000221916
- Chromosome
- 19
- Canonical length
- 129 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for C19orf73 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
129 residues, UniProt reviewed canonical sequence.
>Q9NVV2|C19orf73
1 MRLKVGFQGG GCFRKDALCL EGGVSARWAR APHSAPLRPP RELHAAPPPA TPTQTVVRPA
61 GFPRRTRLMV RSAPPTQRPP TGSGCVSGLW RKGLGLRPQT LLRVGSVVLS SAPALRPRLG
121 PCLRPPPSDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C19orf73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.76
- Highest tissue expression
- 7.1 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 7.1 nTPM
- pancreas: 4.6 nTPM
- basal ganglia: 3.7 nTPM
- pituitary gland: 3.7 nTPM
- cerebral cortex: 3.6 nTPM
- hippocampal formation: 3.5 nTPM
Single-cell type
- epididymal principal cells: 23 nCPM
- tuft cells: 12 nCPM
- esophageal suprabasal cells: 8.7 nCPM
- undifferentiated spermatogonia: 7.8 nCPM
- esophageal basal cells: 7.7 nCPM
- paneth cells: 7.7 nCPM
Immune cell
- NK-cell: 5 nTPM
- naive B-cell: 4.4 nTPM
- myeloid DC: 3.4 nTPM
- non-classical monocyte: 2.8 nTPM
- MAIT T-cell: 2.7 nTPM
- plasmacytoid DC: 2.7 nTPM
Brain region
- cerebellum: 8.2 nTPM
- cerebral cortex: 5.4 nTPM
- white matter: 5.3 nTPM
- medulla oblongata: 4.6 nTPM
- pons: 4.3 nTPM
- spinal cord: 4.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0.08
- gnomAD missense Z
- -0.93
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF5538
- Family of unknown function (DUF5538)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C19orf73 as an antibody target. Whether an autoantibody or antibody against C19orf73 could matter depends on whether native C19orf73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C19orf73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C19orf73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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