Seroatlas · Human Serome Atlas

C19orf67

UPF0575 protein C19orf67

Also known as: CS067_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJJ6
Gene
C19orf67
Ensembl
ENSG00000188032
Chromosome
19
Canonical length
358 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within in utero embryonic development. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>A6NJJ6|C19orf67
     1  MATEQWFEGS LPLDPGETPP PDALEPGTPP CGDPSRSTPP GRPGNPSEPD PEDAEGRLAE
    61  ARASTSSPKP LVPRPGPAPP RLSLDTLFSP ITQQLRYLLK KADDFQSYLL YSRDQVQKEQ
   121  LAKAMPTFLQ MCEPYFLYLE AAARSIPPIY GPLQELVRKG LLEISQQLTL RLEQLVLMYA
   181  SFGFVDLEEM NPLSISCFFC GRFSISLSHE VSIFRYCAPT AYTASRFPRY LYKKMRWHLE
   241  ATPEAPGRGQ DSLVDYYFLC YRDTWEDTGQ SPANSCPQIQ KLWSIGRWVP LGPAEDDLYS
   301  WILCPQPLGD YQQLLTIGFE EPTPTLATDL LVQILTGQAG QARPPSAAGP AGWAAQGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C19orf67 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.4 nTPM
  • stomach: 0.2 nTPM
  • cervix: 0.1 nTPM
  • colon: 0.1 nTPM
  • fallopian tube: 0.1 nTPM
  • kidney: 0.1 nTPM

Single-cell type

  • late primary spermatocytes: 9.6 nCPM
  • late spermatids: 9.3 nCPM
  • early spermatids: 8 nCPM
  • oocytes: 4.6 nCPM
  • respiratory ciliated cells: 0.3 nCPM
  • renal collecting duct intercalated cells: 0.2 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 1 nTPM
  • cerebral cortex: 0.8 nTPM
  • midbrain: 0.8 nTPM
  • spinal cord: 0.8 nTPM
  • thalamus: 0.8 nTPM
  • white matter: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
1.75
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF3314
  • Protein of unknown function (DUF3314)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C19orf67 as an antibody target. Whether an autoantibody or antibody against C19orf67 could matter depends on whether native C19orf67 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C19orf67 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C19orf67 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C19orf67. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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