C19orf53
Leydig cell tumor 10 kDa protein homolog
Also known as: HSPC023, L10K_HUMAN, LYDG10
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UNZ5
- Gene
- C19orf53
- Ensembl
- ENSG00000104979
- Chromosome
- 19
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
No narrative summary is available for C19orf53 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q9UNZ5|C19orf53
1 MAQGQRKFQA HKPAKSKTAA AASEKNRGPR KGGRVIAPKK ARVVQQQKLK KNLEVGIRKK
61 IEHDVVMKAS SSLPKKLALL KAPAKKKGAA AATSSKTPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C19orf53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 204 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 204 nTPM
- skeletal muscle: 158 nTPM
- amygdala: 150 nTPM
- heart muscle: 144 nTPM
- cerebral cortex: 141 nTPM
- basal ganglia: 139 nTPM
Single-cell type
- late spermatids: 1,070 nCPM
- esophageal apical cells: 682 nCPM
- esophageal suprabasal cells: 652 nCPM
- decidual stromal cells: 521 nCPM
- esophageal basal cells: 512 nCPM
- extravillous trophoblasts: 504 nCPM
Immune cell
- total PBMC: 497 nTPM
- T-reg: 339 nTPM
- memory B-cell: 335 nTPM
- naive B-cell: 323 nTPM
- naive CD4 T-cell: 319 nTPM
- naive CD8 T-cell: 291 nTPM
Brain region
- hypothalamus: 81 nTPM
- cerebellum: 74 nTPM
- midbrain: 73 nTPM
- medulla oblongata: 71 nTPM
- thalamus: 69 nTPM
- pons: 68 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0.06
- gnomAD missense Z
- -1.57
- DepMap mean gene effect
- -0.61
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterised protein family UPF0390
- Protein of unknown function (DUF2462)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C19orf53 as an antibody target. Whether an autoantibody or antibody against C19orf53 could matter depends on whether native C19orf53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C19orf53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C19orf53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...