Seroatlas · Human Serome Atlas

C19orf47

Uncharacterized protein C19orf47

Also known as: CS047_HUMAN, FLJ36888

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9M1
Gene: C19orf47
Ensembl: ENSG00000160392
Chromosome: 19
Canonical length: 422 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q8N9M1|C19orf47
     1  MVMAALSLVA ACWGRAAADE SVQLPAAPGS SVRARETMVS VTMATSEWIQ FFKEAGIPPG
    61  PAVNYAVMFV DNRIQKSMLL DLNKEIMNEL GVTVVGDIIA ILKHAKVVHR QDMCKAATES
   121  VPCSPSPLAG EIRRGTSAAS RMITNSLNHD SPPSTPPRRP DTSTSKISVT VSNKMAAKSA
   181  KATAALARRE EESLAVPAKR RRVTAEMEGK YVINMPKGTT PRTRKILEQQ QAAKGLHRTS
   241  VFDRLGAETK ADTTTGSKPT GVFSRLGATP ETDEDLAWDS DNDSSSSVLQ YAGVLKKLGR
   301  GPAKASPQPA LTVKAKATSS ATTAAAPTLR RLALSSRSGL ERKPESLSKV SIIKRLGAAA
   361  LVPEAQDSQV TSTKSKSSAE VKVTIKRTLV GPRGSSSSEG LGAQMDHAGT VSVFKRLGRR
   421  TF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C19orf47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 335 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 335 nTPM
heart muscle: 164 nTPM
tongue: 128 nTPM
testis: 37 nTPM
cerebral cortex: 15 nTPM
spinal cord: 14 nTPM

Single-cell type

thymic myoid cells: 117 nCPM
late spermatids: 44 nCPM
late primary spermatocytes: 37 nCPM
myonuclei: 22 nCPM
syncytiotrophoblasts: 21 nCPM
extravillous trophoblasts: 20 nCPM

Immune cell

basophil: 29 nTPM
neutrophil: 7.3 nTPM
eosinophil: 6.7 nTPM
memory CD4 T-cell: 3 nTPM
memory CD8 T-cell: 2.7 nTPM
naive B-cell: 2.5 nTPM

Brain region

white matter: 43 nTPM
amygdala: 42 nTPM
basal ganglia: 42 nTPM
medulla oblongata: 41 nTPM
midbrain: 40 nTPM
cerebral cortex: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.17
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sterile alpha motif/pointed domain superfamily
Uncharacterized protein C19orf47-like
C19orf47, SAM domain
Domain of unknown function DUF5577
Family of unknown function (DUF5577)
SAM domain (Sterile alpha motif)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C19orf47 as an antibody target. Whether an autoantibody or antibody against C19orf47 could matter depends on whether native C19orf47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C19orf47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C19orf47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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