Seroatlas · Human Serome Atlas

C19orf44

Uncharacterized protein C19orf44

Also known as: CS044_HUMAN, FLJ21742

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6X5
Gene
C19orf44
Ensembl
ENSG00000105072
Chromosome
19
Canonical length
657 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for C19orf44 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q9H6X5|C19orf44
     1  MASARKASRP MRDVFGDFSD VSLEDSTMEE IRNFQISRNL TKIAPGHSRF LKRNQTLDEK
    61  HLLLKENPVL GSGPRLASCR PPTTASRIRA NAALMKLAQL ETRIMNRKLQ RNLSDTESDS
   121  MTADAGLPKR ADRILSGGAL ELASQNTDKT SQNQARELPV TENNAQNAKV SRFLKKKQAP
   181  VENISPEAPA GKERTLQTPK QKEPARTFDS PDSDEEEMKV LLGSLMDSSR EKNTNQGFSS
   241  ANVSEEEERK LFSVPSQLRA FTVPSVELSS AKPSQTSHLP TSLAADRTLH STRSRADYPQ
   301  SHVSSDTASH TPSVSITGAF SNSVSLKMGH VKLVSSPGRS EAETVDEPVS EGADDSLDEF
   361  RINILSLDGL APAVSENSDL EQEEESAQRQ KTAGKIFRAE ASTGQDAPRQ AQARSWASQG
   421  KAASAEGDES EVSEHLSASS ASAIQQDSTS SMQPPSEAPM VNTVSSAYSE DFENSPSLTA
   481  SEPTAHSKES LDRTLDALSE SSSSVKTDLP QTAESRKKSG RHVTRVLVKD TAVQTPDPAF
   541  TYEWTKVASM AAMGPALGGA YVDPTPIANH VISADAIEAL TAYSPAVLAL HDVLKQQLSL
   601  TQQFIQASRH LHASLLRSLD ADSFHYHTLE EAKEYIRCHR PAPLTMEDAL EEVNKEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C19orf44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • ovary: 7.6 nTPM
  • pituitary gland: 6.7 nTPM
  • choroid plexus: 6.6 nTPM
  • cervix: 6.5 nTPM
  • fallopian tube: 6.5 nTPM

Single-cell type

  • late spermatids: 127 nCPM
  • early spermatids: 60 nCPM
  • epicardial cells: 32 nCPM
  • late primary spermatocytes: 30 nCPM
  • cardiomyocytes: 30 nCPM
  • ependymal cells: 26 nCPM

Immune cell

  • basophil: 3.2 nTPM
  • memory B-cell: 1.4 nTPM
  • naive B-cell: 1 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • neutrophil: 0.8 nTPM
  • memory CD4 T-cell: 0.6 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • medulla oblongata: 13 nTPM
  • midbrain: 13 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 11 nTPM
  • amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Domain of unknown function DUF4614
  • Uncharacterized protein C19orf44-like
  • Domain of unknown function (DUF4614)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C19orf44 as an antibody target. Whether an autoantibody or antibody against C19orf44 could matter depends on whether native C19orf44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C19orf44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C19orf44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C19orf44. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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