Seroatlas · Human Serome Atlas

C18orf63

Uncharacterized protein C18orf63

Also known as: CR063_HUMAN, DKFZP781G0119

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68DL7
Gene: C18orf63
Ensembl: ENSG00000206043
Chromosome: 18
Canonical length: 685 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for C18orf63 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

685 residues, UniProt reviewed canonical sequence.

>Q68DL7|C18orf63
     1  MNDSRQQSLF FITLPDLNKL CAVRIILSNK VADTEIRTIQ MKMCRQLLFL HQDILTSPVS
    61  GILNQIWVVM AIPFYKARKL NAYVEKYGAK MEAPQRVIPV ILQNCLSYSF MARLAPAWNR
   121  TGHLLIQGRD FLSQMGKQSA VVLNINVTET QVCLSIEACT IRLPAPELKE FEISQSIIKD
   181  FHANKHAVIE RHSILSNWCY VLPSMKMGQI INIFHAIPAA CPFHSYGDFQ RHWDALYGYK
   241  LPGDCGKIKI YCNIYFKMLG ERTFTYPLSC IRSQPMQFFP RVDSEVVLKS FLSDLKSKLP
   301  HICGFPIKMT SKPCYYTQEL TKPNIQEHKV KPPNLTTKKM LRASLTQATS RKPACAQSLL
   361  PCSVAVDHKV ELSVSQPTSG IFSALHLQPE SVQGRKKSLS IRAPQVHSEV LMPNRGNTQV
   421  QHTNLSSQSN ITPKFVPVFK NRLLQMNKNT SVLGSPKRKQ HDVTQSKLFS LKTSMIQHDK
   481  LNLGPAIKNR YSSNIQMQAA NNLNQENSRP LQEKNTESSE NMTKFPSSRG KSTVSLNKNK
   541  QLSNSAVFVV SNNNLGVVKS AVDFQMKGKE NLTGKGITQI LGKSHGSLKL KRQPHIFESD
   601  GETEDPRLLQ QQSENQAKEV GTSDHRLIVS KIAHRSKRKL CPESSKTSKK HHSDTVHYGQ
   661  SSSSKKQILD SDKSKLKKSL IIHNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C18orf63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

testis: 9.2 nTPM
breast: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 240 nCPM
breast lactating cells: 45 nCPM
undifferentiated spermatogonia: 15 nCPM
late primary spermatocytes: 7.2 nCPM
alveolar cells type 2: 4.1 nCPM
differentiating spermatogonia: 3.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.02
DepMap dependency class: none

OntologyGO

Biological processes

male gonad development

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4708
Domain of unknown function (DUF4708)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C18orf63 as an antibody target. Whether an autoantibody or antibody against C18orf63 could matter depends on whether native C18orf63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C18orf63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C18orf63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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