C18orf32
UPF0729 protein C18orf32
Also known as: CR032_HUMAN, FLJ23458
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TCD1
- Gene
- C18orf32
- Ensembl
- ENSG00000177576
- Chromosome
- 18
- Canonical length
- 76 aa
- Protein class
- Disease related genes, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
76 residues, UniProt reviewed canonical sequence.
>Q8TCD1|C18orf32
1 MVCIPCIVIP VLLWIYKKFL EPYIYPLVSP FVSRIWPKKA IQESNDTNKG KVNFKGADMN
61 GLPTKGPTEI CDKKKDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C18orf32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- retina: 28 nTPM
- choroid plexus: 20 nTPM
- spinal cord: 19 nTPM
- parathyroid gland: 18 nTPM
- midbrain: 14 nTPM
- amygdala: 11 nTPM
Single-cell type
- parietal cells: 313 nCPM
- early spermatids: 258 nCPM
- late spermatids: 251 nCPM
- gastric chief cells: 140 nCPM
- epididymal clear cells: 106 nCPM
- oligodendrocytes: 96 nCPM
Immune cell
- neutrophil: 36 nTPM
- basophil: 27 nTPM
- eosinophil: 24 nTPM
- non-classical monocyte: 11 nTPM
- total PBMC: 10 nTPM
- plasmacytoid DC: 9.4 nTPM
Brain region
- white matter: 44 nTPM
- cerebellum: 39 nTPM
- medulla oblongata: 37 nTPM
- spinal cord: 36 nTPM
- pons: 36 nTPM
- basal ganglia: 34 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about C18orf32.
Disease | AllUniProt
Conditions C18orf32 is implicated in, by any mechanism.
- Glycosylphosphatidylinositol biosynthesis defect 25 (GPIBD25) MIM:619985
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0.2
- gnomAD missense Z
- 0.13
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- UPF0729 protein C18orf32-like
- Domain of unknown function (DUF4512)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C18orf32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C18orf32 as an antibody target. Whether an autoantibody or antibody against C18orf32 could matter depends on whether native C18orf32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C18orf32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C18orf32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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