Seroatlas · Human Serome Atlas

C17orf99

Protein IL-40

Also known as: GLPG464, IL40_HUMAN, UNQ464

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX52
Gene: C17orf99
Ensembl: ENSG00000187997
Chromosome: 17
Canonical length: 265 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; mature B cell differentiation involved in immune response; and positive regulation of immunoglobulin production in mucosal tissue. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q6UX52|C17orf99
     1  MGLPGLFCLA VLAASSFSKA REEEITPVVS IAYKVLEVFP KGRWVLITCC APQPPPPITY
    61  SLCGTKNIKV AKKVVKTHEP ASFNLNVTLK SSPDLLTYFC WASSTSGAHV DSARLQMHWE
   121  LWSKPVSELR ANFTLQDRGA GPRVEMICQA SSGSPPITNS LIGKDGQVHL QQRPCHRQPA
   181  NFSFLPSQTS DWFWCQAANN ANVQHSALTV VPPGGDQKME DWQGPLESPI LALPLYRSTR
   241  RLSEEEFGGF RIGNGEVRGR KAAAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf99 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 8.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 8.2 nTPM
thymus: 1.1 nTPM
lymph node: 0.7 nTPM
tonsil: 0.6 nTPM
fallopian tube: 0.5 nTPM
skin: 0.4 nTPM

Single-cell type

erythrocyte progenitors: 41 nCPM
erythrocytes: 6.3 nCPM
epididymal basal cells: 5.1 nCPM
megakaryocyte-erythroid progenitors: 4.8 nCPM
enteric stem cells: 4.2 nCPM
colonocytes: 3.8 nCPM

Immune cell

naive B-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.13
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf99 as an antibody target. Whether an autoantibody or antibody against C17orf99 could matter depends on whether native C17orf99 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf99 is annotated as secreted, so native C17orf99 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C17orf99 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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