Seroatlas · Human Serome Atlas

C17orf78

Uncharacterized protein C17orf78

Also known as: CQ078_HUMAN, FLJ39647

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4C9
Gene: C17orf78
Ensembl: ENSG00000278505
Chromosome: 17
Canonical length: 275 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q8N4C9|C17orf78
     1  MDTILVFSLI IASYDANKKD LRDSSCRLEQ LPGIFPKDVR SIRELQMQET HTETKRTTFI
    61  QNRTIATLQC LGSDSKVKVN LVYLERRPKV KHILKNLRII AAPRRNSSAS SSCHLIPTSK
   121  FQTGSLLKGK AFLPGISQCK VLGASSETFP TTAPSITPGN KEGEKTTSTD TDENLEKRQK
   181  WSIVVKILIA VTLLLSGVAI IVFVIFEVPC PYQCLGARKL CQCQWLWRWQ KKGGQPPGTA
   241  ESKPDSQPQK VGQDAANSSN PKKAAEITVI HQTYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

duodenum: 120 nTPM
small intestine: 58 nTPM
testis: 1.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

enterocytes: 16 nCPM
epicardial cells: 6.8 nCPM
other brain neurons: 4.4 nCPM
brain excitatory neurons: 3.3 nCPM
brain inhibitory neurons: 3.3 nCPM
medullary thymic epithelial cells: 2.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.9 nTPM
hypothalamus: 2.9 nTPM
basal ganglia: 2.8 nTPM
cerebellum: 2.5 nTPM
hippocampal formation: 2.3 nTPM
pons: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4711
Domain of unknown function (DUF4711)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf78 as an antibody target. Whether an autoantibody or antibody against C17orf78 could matter depends on whether native C17orf78 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf78 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C17orf78 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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