Seroatlas · Human Serome Atlas

C17orf75

Protein Njmu-R1

Also known as: NJMU_HUMAN, NJMU-R1, SRI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAS0
Gene: C17orf75
Ensembl: ENSG00000108666
Chromosome: 17
Canonical length: 396 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Involved in intracellular protein transport and vesicle tethering to Golgi. Located in cytoplasmic vesicle; cytosol; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q9HAS0|C17orf75
     1  MLPSLQESMD GDEKELESSE EGGSAEERRL EPPSSSHYCL YSYRGSRLAQ QRGDSEDGSP
    61  SGTNAETPSG DDFSLSLADT NLPSEVEPEL RSFIAKRLSR GAVFEGLGNV ASVELKIPGY
   121  RVGCYYCLFQ NEKLLPETVT IDSERNPSEY VVCFLGGSEK GLELFRLELD KYIQGLKNNM
   181  NCEARGLESH IKSYLSSWFE DVVCPIQRVV LLFQEKLTFL LHAALSYTPV EVKESDEKTK
   241  RDINRFLSVA SLQGLIHEGT MTSLCMAMTE EQHKSVVIDC SSSQPQFCNA GSNRFCEDWM
   301  QAFLNGAKGG NPFLFRQVLE NFKLKAIQDT NNLKRFIRQA EMNHYALFKC YMFLKNCGSG
   361  DILLKIVKVE HEEMPEAKNV IAVLEEFMKE ALDQSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf75 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

testis: 27 nTPM
parathyroid gland: 26 nTPM
retina: 24 nTPM
kidney: 21 nTPM
choroid plexus: 18 nTPM
heart muscle: 18 nTPM

Single-cell type

early primary spermatocytes: 85 nCPM
late primary spermatocytes: 63 nCPM
respiratory ionocytes: 48 nCPM
cytotrophoblasts: 39 nCPM
fallopian tube ciliated cells: 36 nCPM
parietal cells: 35 nCPM

Immune cell

basophil: 35 nTPM
MAIT T-cell: 20 nTPM
naive B-cell: 20 nTPM
T-reg: 20 nTPM
NK-cell: 19 nTPM
memory B-cell: 18 nTPM

Brain region

cerebral cortex: 20 nTPM
choroid plexus: 20 nTPM
cerebellum: 19 nTPM
hypothalamus: 18 nTPM
pons: 18 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.34
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein Njmu-R1
Njmu-R1-like protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C17orf75 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TBC1D23

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf75 as an antibody target. Whether an autoantibody or antibody against C17orf75 could matter depends on whether native C17orf75 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf75 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C17orf75 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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