Seroatlas · Human Serome Atlas

C17orf67

Uncharacterized protein C17orf67

Also known as: CQ067_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0P5P2
Gene
C17orf67
Ensembl
ENSG00000214226
Chromosome
17
Canonical length
90 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>Q0P5P2|C17orf67
     1  MKTLPVLVLS LTLLTVFSET SPILTEKQAK QLLRSRRQDR PSKPGFPDEP MREYMHHLLA
    61  LEHRAEEQFL EHWLNPHCKP HCDRNRIHPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf67 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
5.1 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 5.1 nTPM
  • spleen: 2.5 nTPM
  • liver: 2.1 nTPM
  • cervix: 1.9 nTPM
  • endometrium: 1.7 nTPM
  • ovary: 1.7 nTPM

Single-cell type

  • pancreatic duct cells: 65 nCPM
  • lymphatic endothelial cells: 48 nCPM
  • bergmann glia: 41 nCPM
  • hematopoietic stem cells: 36 nCPM
  • microglia: 35 nCPM
  • vascular endothelial cells: 35 nCPM

Immune cell

  • memory B-cell: 1.5 nTPM
  • T-reg: 1.5 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • naive B-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • memory CD4 T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 9.3 nTPM
  • hypothalamus: 7.2 nTPM
  • white matter: 7.1 nTPM
  • amygdala: 6.2 nTPM
  • midbrain: 5.9 nTPM
  • pons: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0
gnomAD missense Z
-0.2
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4543
  • Domain of unknown function (DUF4543)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf67 as an antibody target. Whether an autoantibody or antibody against C17orf67 could matter depends on whether native C17orf67 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf67 is annotated as secreted, so native C17orf67 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C17orf67 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C17orf67. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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