Seroatlas · Human Serome Atlas

C17orf58

UPF0450 protein C17orf58

Also known as: CQ058_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M2W7
Gene: C17orf58
Ensembl: ENSG00000186665
Chromosome: 17
Canonical length: 339 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q2M2W7|C17orf58
     1  MTARAFWLLC LIVGSSPEAP VAERKTSPPH SRKPDSRGCP SAEETPGPRA QPLLEAPQRP
    61  RAAEVAPAAR AWPDPRRRKP PPPADNQASF REAARAPAGP PGPRLAQAEN RASPRREPAS
   121  EDAPRRARSR ALRFPAARPP ALATEGSAGH AHPNRPRAAA LAPGPAPAPP PRFSLSFGLS
   181  PPQRDAEPGA EPCARACRSD LDEREAFCES EFAVNGIVHD VDVLGAGIRL VTLLVDRDGL
   241  YKMNRLYLTP DGFFFRVHML ALDSSSCNKP CPEFKPGSRY IVMGHIYHKR RQLPTALLQV
   301  LRGRLRPGDG LLRSSSSYVK RFNRKREGQI QGAIHTQCI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

placenta: 34 nTPM
cervix: 25 nTPM
breast: 16 nTPM
endometrium: 14 nTPM
adipose tissue: 11 nTPM
smooth muscle: 10 nTPM

Single-cell type

decidual stromal cells: 69 nCPM
breast hormone-responsive cells: 54 nCPM
oocytes: 37 nCPM
fibroblasts: 36 nCPM
cytotrophoblasts: 36 nCPM
endometrial stromal cells: 32 nCPM

Immune cell

basophil: 8.9 nTPM
eosinophil: 5 nTPM
non-classical monocyte: 5 nTPM
myeloid DC: 3.9 nTPM
intermediate monocyte: 2.9 nTPM
memory B-cell: 2.9 nTPM

Brain region

cerebral cortex: 3.8 nTPM
basal ganglia: 3.4 nTPM
white matter: 3.4 nTPM
spinal cord: 3.3 nTPM
cerebellum: 3.1 nTPM
medulla oblongata: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0.19
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular matrix

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf58 as an antibody target. Whether an autoantibody or antibody against C17orf58 could matter depends on whether native C17orf58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf58 is annotated as secreted, so native C17orf58 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C17orf58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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