C17orf50
Uncharacterized protein C17orf50
Also known as: CQ050_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WW18
- Gene
- C17orf50
- Ensembl
- ENSG00000270806
- Chromosome
- 17
- Canonical length
- 174 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for C17orf50 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
174 residues, UniProt reviewed canonical sequence.
>Q8WW18|C17orf50
1 MDKHGVKTPL WKKETEELRA EDAEQEEGKE GSEDEDEDNQ RPLEDSATEG EEPPRVAEEG
61 EGRERRSVSY CPLRQESSTQ QVALLRRADS GFWGWLGPLA LLGGLTAPTD RKRSLPEEPC
121 VLEIRRRPPR RGGCACCELL FCKKCRSLHS HPAYVAHCVL DHPDLGKAGA AGNSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C17orf50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 94 nTPM
Expression across tissuesHPA
Tissue
- testis: 94 nTPM
- basal ganglia: 1.1 nTPM
- cerebellum: 0.7 nTPM
- hypothalamus: 0.5 nTPM
- amygdala: 0.4 nTPM
- cerebral cortex: 0.4 nTPM
Single-cell type
- late spermatids: 2,114 nCPM
- early spermatids: 695 nCPM
- late primary spermatocytes: 596 nCPM
- epididymal principal cells: 14 nCPM
- epicardial cells: 6.8 nCPM
- hematopoietic stem cells: 5.3 nCPM
Immune cell
- naive CD8 T-cell: 1.4 nTPM
- plasmacytoid DC: 1.4 nTPM
- naive CD4 T-cell: 1.2 nTPM
- gdT-cell: 0.8 nTPM
- memory B-cell: 0.8 nTPM
- MAIT T-cell: 0.7 nTPM
Brain region
- amygdala: 5.2 nTPM
- basal ganglia: 4.5 nTPM
- hypothalamus: 4.3 nTPM
- midbrain: 4.3 nTPM
- cerebral cortex: 4.2 nTPM
- hippocampal formation: 3.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.31
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Domain of unknown function DUF4637
- C17orf50 C-terminal zinc-binding domain
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C17orf50 as an antibody target. Whether an autoantibody or antibody against C17orf50 could matter depends on whether native C17orf50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C17orf50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C17orf50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...