Seroatlas · Human Serome Atlas

C17orf114

Uncharacterized protein C17orf114

Also known as: CQ114_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUV1
Gene
C17orf114
Ensembl
ENSG00000262165
Chromosome
17
Canonical length
79 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C17orf114 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>A0A1B0GUV1|C17orf114
     1  MGLKGAWCFP WCGCRRQRGT ERGAGLSPAA PPDPSPAIAP TMAEGGVPSP GPGAYFSRKA
    61  RLSFRHQLHD IASANDSTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf114 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
6.3 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 6.3 nTPM
  • midbrain: 5.9 nTPM
  • basal ganglia: 4.5 nTPM
  • amygdala: 4.3 nTPM
  • hypothalamus: 4.2 nTPM
  • cerebral cortex: 3.9 nTPM

Single-cell type

  • esophageal apical cells: 24 nCPM
  • undifferentiated spermatogonia: 11 nCPM
  • cholangiocytes: 10 nCPM
  • ependymal cells: 8.5 nCPM
  • fallopian tube ciliated cells: 7.8 nCPM
  • retinal ganglion cells: 7.7 nCPM

Immune cell

  • classical monocyte: 0.5 nTPM
  • naive CD8 T-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • naive B-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • non-classical monocyte: 0.4 nTPM

Brain region

  • medulla oblongata: 7.7 nTPM
  • basal ganglia: 6.4 nTPM
  • white matter: 5.1 nTPM
  • spinal cord: 4.4 nTPM
  • midbrain: 4.2 nTPM
  • thalamus: 4.2 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf114 as an antibody target. Whether an autoantibody or antibody against C17orf114 could matter depends on whether native C17orf114 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf114 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C17orf114 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C17orf114. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...