Seroatlas · Human Serome Atlas

C17orf113

Uncharacterized protein C17orf113

Also known as: CQ113_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUU1
Gene
C17orf113
Ensembl
ENSG00000267221
Chromosome
17
Canonical length
675 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for C17orf113 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>A0A1B0GUU1|C17orf113
     1  MVPPGKKPAG EASNSNKKCK RYFNEHWKEE FTWLDFDYER KLMFCLECRQ ALVRNKHGKA
    61  ENAFTVGTDN FQRHALLRHV TSGAHRQALA VNQGQPPFEG QAEGGGACPG LATTPASRGV
   121  KVELDPAKVA VLTTVYCMAK EDVPNDRCSA LLELQRFNLC QALLGTEHGD YYSPRRVRDM
   181  QVAIASVLHT EACQRLKASP YVGLVLDETR DWPESHSLAL FATSVSPCDG QPATTFLGSV
   241  ELQEGEATAG QLLDILQAFG VSAPKLAWLS SSLPSERLGS VGPQLRATCP LLAELHCLPG
   301  RTDPEPPAYL GQYESILDAL FRLHGGPSSH LVPELRAALD LAAIDLAGPR PVPWASLLPV
   361  VEAVAEAWPG LVPTLEAAAL ASPVAGSLAL ALRQFTFVAF THLLLDALPS VQKLSLVLQA
   421  EEPDLALLQP LVMAAAASLQ AQRGSGGARL QGFLQELASM DPDASSGRCT YRGVELLGYS
   481  EAAVRGLEWL RGSFLDSMRK GLQDSYPGPS LDAVAAFAAI FDPRRYPQAP EELGTHGEGA
   541  LRVLLRGFAP AVVRQRALGD FALFKRVVFG LGRLGPRALC TQLACAHSEL HELFPDFAAL
   601  AALALALPAG AGLLDKVGRS RELRWWGQSG AGEGRGGHMV KIAVDGPPLH EFDFGLAVEF
   661  LESGWGEGFL GSQLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf113 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 3.6 nTPM
  • pancreas: 3 nTPM
  • testis: 2.7 nTPM
  • kidney: 2.6 nTPM
  • ovary: 2.3 nTPM
  • pituitary gland: 2.1 nTPM

Single-cell type

  • erythrocytes: 0.2 nCPM
  • cardiomyocytes: 0.1 nCPM
  • corticotrophs: 0.1 nCPM
  • fallopian tube ciliated cells: 0.1 nCPM
  • gonadotrophs: 0.1 nCPM
  • respiratory ciliated cells: 0.1 nCPM

Immune cell

  • plasmacytoid DC: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 8.7 nTPM
  • white matter: 6.6 nTPM
  • cerebral cortex: 5.3 nTPM
  • amygdala: 5.1 nTPM
  • thalamus: 5.1 nTPM
  • basal ganglia: 4.9 nTPM

Protein domainsUniProt · Pfam · InterPro

  • C17orf113, probable zinc finger
  • C17orf113 probable zinc finger

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf113 as an antibody target. Whether an autoantibody or antibody against C17orf113 could matter depends on whether native C17orf113 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf113 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C17orf113 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C17orf113. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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