C17orf107
Uncharacterized protein C17orf107
Also known as: CQ107_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZR85
- Gene
- C17orf107
- Ensembl
- ENSG00000205710
- Chromosome
- 17
- Canonical length
- 190 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for C17orf107 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
190 residues, UniProt reviewed canonical sequence.
>Q6ZR85|C17orf107
1 MKGTPSSLDT LMWIYHFHSS TEVALQPPLL SSLELSVAAA HEYLEQRFRE LKSLEPPEPK
61 MQGMLPAPKP TLGLVLREAT ASLVSFGTTL LEISALWLQQ EARRLDGSAG PAPDGRDPGA
121 ALSRVAQAAG QGVRQAGAAV GASARLLVQG AWLCLCGRGL QGSASFLRQS QQQLGLGIPG
181 EPVSSGHGVSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C17orf107 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- pituitary gland: 24 nTPM
- heart muscle: 14 nTPM
- salivary gland: 12 nTPM
- liver: 5.1 nTPM
- cerebellum: 4.5 nTPM
- pancreas: 4.4 nTPM
Single-cell type
- late spermatids: 448 nCPM
- early spermatids: 65 nCPM
- neutrophils: 28 nCPM
- mast cells: 18 nCPM
- epididymal principal cells: 12 nCPM
- monocytes: 11 nCPM
Immune cell
- neutrophil: 2.9 nTPM
- eosinophil: 0.4 nTPM
- MAIT T-cell: 0.4 nTPM
- naive CD8 T-cell: 0.3 nTPM
- naive CD4 T-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- cerebellum: 25 nTPM
- hypothalamus: 15 nTPM
- cerebral cortex: 14 nTPM
- basal ganglia: 9.9 nTPM
- white matter: 9.3 nTPM
- hippocampal formation: 9.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.5
- gnomAD pLI
- 0.07
- gnomAD missense Z
- 0.5
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterized protein C17orf107
- Family of unknown function (DUF5536)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C17orf107 as an antibody target. Whether an autoantibody or antibody against C17orf107 could matter depends on whether native C17orf107 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C17orf107 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C17orf107 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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