Seroatlas · Human Serome Atlas

C17orf100

Uncharacterized protein C17orf100

Also known as: CQ100_HUMAN, LOC388327

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MU93
Gene
C17orf100
Ensembl
ENSG00000256806
Chromosome
17
Canonical length
118 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

No narrative summary is available for C17orf100 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>A8MU93|C17orf100
     1  MASARGAKQS SPRVGTTRYT ETSTVRVETS SHRVETSSRR VETSQRRSEG PSLSPSGKRL
    61  PRILEASSRH VESSSQRTET TSRHVRASSL RVETSLHCAE SPTPRAKPAA RQNEKTAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C17orf100 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
9.1 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 9.1 nTPM
  • skin: 6.9 nTPM
  • basal ganglia: 5.2 nTPM
  • cerebral cortex: 5.1 nTPM
  • spinal cord: 5 nTPM
  • hypothalamus: 4.9 nTPM

Single-cell type

  • late spermatids: 24 nCPM
  • epididymal principal cells: 23 nCPM
  • early spermatids: 17 nCPM
  • late primary spermatocytes: 14 nCPM
  • enterocytes: 11 nCPM
  • early primary spermatocytes: 11 nCPM

Immune cell

  • basophil: 3.9 nTPM
  • eosinophil: 3.9 nTPM
  • naive B-cell: 2.5 nTPM
  • naive CD4 T-cell: 2.5 nTPM
  • memory B-cell: 2.2 nTPM
  • memory CD4 T-cell: 2.2 nTPM

Brain region

  • basal ganglia: 11 nTPM
  • cerebral cortex: 10 nTPM
  • hypothalamus: 10 nTPM
  • midbrain: 8.3 nTPM
  • white matter: 8.2 nTPM
  • spinal cord: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0.13
gnomAD missense Z
0.55

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C17orf100 as an antibody target. Whether an autoantibody or antibody against C17orf100 could matter depends on whether native C17orf100 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C17orf100 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C17orf100 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C17orf100. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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