Seroatlas · Human Serome Atlas

C16orf96

Uncharacterized protein C16orf96

Also known as: CP096_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNT2
Gene: C16orf96
Ensembl: ENSG00000205832
Chromosome: 16
Canonical length: 1141 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

No narrative summary is available for C16orf96 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1141 residues, UniProt reviewed canonical sequence.

>A6NNT2|C16orf96
     1  MSFSLTFTEL ANIAIPQCGV LNFKALHLLL HGILEHIHMA ELKKVLSGDE DFLQTSQVVI
    61  MPREGDAQPI LNPMKRLSNV FDHVVSRLDK LENQLALLQD LPSTAQLLEA SQGTARPVQD
   121  LWHLIKLRKM VEGHDEVMAK SMQTLQDLLT DLHALQVTIT ALRKEVDMLK NMLDKVHPER
   181  MDIFAEDFKI QNWKMVALQR EVASLQNKFK TIPKTEDMVL WSGLHDAMFT SEIGSSPLDL
   241  WQSVEQLPEA ALAQTTKYLE ATRAIQVSEP VQNPQLLQTV WHYEVPELLP EGSSAQAVSL
   301  SRAQEPAQPP ALTPESAPGC TTEFAPGPAP GTEPVPGLEL GLELEPVPAL GPVPGPSVTP
   361  GSLPAPWPVL GPVPAPGAQP PPLGDWPALP RRWPLPQGWP RVGSWPLWDL GVLRPTQPQP
   421  SRAPPPATEF GSLWPRPLQP YQSRQGEALQ LAAVQVKGEE NDVPSLRGLR ERARKDGAPK
   481  DRTRKDGVPK DRGGKDVDPK DRAHKDDVPK DRGGKDVDPK DRAHKDDVPK DRGGKDGDPK
   541  DRVGKDGAPK EAQPKAPQSA LHRLKTTAAI AAAAAAAYAA ATSSAAQAAK VAAKFVKDAP
   601  ATKMAAIATD TAAAGPLGVF ADVLGAGPSR GATESQILGD DSEIYEILSP SYSAASIGPD
   661  PALSQAMVAT KQAMSPEDKK RAVKYSMSHI AQIPVKHDSL KEEFAQLSCN LNQRLSYLAN
   721  MGGPSSLGTT VDILQKKIGS LQKSRLKEEE LERIWGNQIE MMKDRYITLD KAVENLQIRM
   781  DEFKTLQAQI KRLEMNKVNK STMEEELREK ADRSALAGKA SRVDLETVAL ELNEMIQGIL
   841  FKVTIHEDSW KKAMEELSKD VNTKLVHSDL DPLKKEMEEV WKIVRKLLIE GLRLDPDSAA
   901  GFRRKLFKRV KCISCDRPVE MMTGPQLITI RKAHLLSRLR PASANSCEYL QRQQMREQQW
   961  LQLQDLGIQE DCQQDWGDGP QNATSLKCKS CNLLTLYPYG DPHVIDYDSA EVDILGVDGI
  1021  LYKGRVNSQR GAQPLAVAKE LAAVKAPSPP SQSLYDRVHS SALFGAICPP LCPRSSACSA
  1081  ASGPHLTMPA RPPSLPPLLL LPPLIPSLRD PQQAPGSTRL SRAPHIESRV GRKPPEEPAN
  1141  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C16orf96 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

testis: 9.7 nTPM
midbrain: 0.5 nTPM
spinal cord: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM

Single-cell type

late primary spermatocytes: 30 nCPM
endometrial luminal cells: 18 nCPM
early spermatids: 17 nCPM
retinal ganglion cells: 16 nCPM
müller glia: 14 nCPM
retinal bipolar cells: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 2.1 nTPM
basal ganglia: 2 nTPM
midbrain: 1.9 nTPM
white matter: 1.9 nTPM
hypothalamus: 1.8 nTPM
spinal cord: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C16orf96 as an antibody target. Whether an autoantibody or antibody against C16orf96 could matter depends on whether native C16orf96 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C16orf96 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C16orf96 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...