C16orf95
Uncharacterized protein C16orf95
Also known as: CP095_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H693
- Gene
- C16orf95
- Ensembl
- ENSG00000260456
- Chromosome
- 16
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
No narrative summary is available for C16orf95 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q9H693|C16orf95
1 MRASRSPPSP RRCHHHHEAT GAASGAAAGG PGAGCVGLCR LALTPSAQDG RNSTFQTYKK
61 EVCLPRHSMH PGPWAICCEC QTRFGGRLPV SRVEAALPYW VPLSLRPRKQ HPCWMHAAGT
121 TAGGSAVMSA CCPSSSSSRP PTRTSYRLLQ RVCCPSASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C16orf95 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 98 nTPM
Expression across tissuesHPA
Tissue
- testis: 98 nTPM
- liver: 6.6 nTPM
- cerebral cortex: 4.1 nTPM
- midbrain: 4.1 nTPM
- skeletal muscle: 4 nTPM
- amygdala: 3.9 nTPM
Single-cell type
- late spermatids: 285 nCPM
- late primary spermatocytes: 235 nCPM
- early spermatids: 112 nCPM
- early primary spermatocytes: 83 nCPM
- erythrocyte progenitors: 66 nCPM
- megakaryocytes: 43 nCPM
Immune cell
- non-classical monocyte: 3.5 nTPM
- plasmacytoid DC: 3.3 nTPM
- naive CD8 T-cell: 2.9 nTPM
- T-reg: 2.9 nTPM
- intermediate monocyte: 2.7 nTPM
- gdT-cell: 2.6 nTPM
Brain region
- thalamus: 4.8 nTPM
- cerebellum: 4.7 nTPM
- pons: 4.7 nTPM
- midbrain: 4.5 nTPM
- cerebral cortex: 4.3 nTPM
- amygdala: 4.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.22
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4568
- Domain of unknown function (DUF4568)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C16orf95 as an antibody target. Whether an autoantibody or antibody against C16orf95 could matter depends on whether native C16orf95 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C16orf95 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C16orf95 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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