Seroatlas · Human Serome Atlas

C16orf90

Uncharacterized protein C16orf90

Also known as: CP090_HUMAN, LOC646174

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MZG2
Gene
C16orf90
Ensembl
ENSG00000215131
Chromosome
16
Canonical length
182 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C16orf90 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>A8MZG2|C16orf90
     1  MEALVCAFSE LHIREDAVSQ AQGRPGHPDA PPNIYEGGLG SPQPQCPSAQ GSKPKNFRLR
    61  HLRGLGLYLE SHPPPTGQCE SHWLGRLMAG GCLPQPEGTA WALDLPQGTL GPRNSLCSAL
   121  LEARLPRDSL GSSASSSSMD PDKGALPQPS PSRLRPKRSW GTWEEAMCPL CKRTRSGALE
   181  RP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C16orf90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • testis: 47 nTPM
  • skeletal muscle: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 779 nCPM
  • early spermatids: 260 nCPM
  • late primary spermatocytes: 195 nCPM
  • early primary spermatocytes: 12 nCPM
  • sertoli cells: 3.9 nCPM
  • peritubular myoid cells: 2.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.9 nTPM
  • hippocampal formation: 1.6 nTPM
  • amygdala: 1.5 nTPM
  • basal ganglia: 1.5 nTPM
  • cerebral cortex: 1.4 nTPM
  • pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
-0.02
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4644
  • Domain of unknown function (DUF4644)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C16orf90 as an antibody target. Whether an autoantibody or antibody against C16orf90 could matter depends on whether native C16orf90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C16orf90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C16orf90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C16orf90. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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