C16orf89
UPF0764 protein C16orf89
Also known as: CP089_HUMAN, MGC45438
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UX73
- Gene
- C16orf89
- Ensembl
- ENSG00000153446
- Chromosome
- 16
- Canonical length
- 402 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene is expressed predominantly in the thyroid. Based on expression patterns similar to thyroid transcription factors and proteins, this gene may function in the development and function of the thyroid. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Canonical amino-acid sequenceUniProt
402 residues, UniProt reviewed canonical sequence.
>Q6UX73|C16orf89
1 MASLGLLLLL LLTALPPLWS SSLPGLDTAE SKATIADLIL SALERATVFL EQRLPEINLD
61 GMVGVRVLEE QLKSVREKWA QEPLLQPLSL RVGMLGEKLE AAIQRSLHYL KLSDPKYLRE
121 FQLTLQPGFW KLPHAWIHTD ASLVYPTFGP QDSFSEERSD VCLVQLLGTG TDSSEPCGLS
181 DLCRSLMTKP GCSGYCLSHQ LLFFLWARMR GCTQGPLQQS QDYINLFCAN MMDLNRRAEA
241 IGYAYPTRDI FMENIMFCGM GGFSDFYKLR WLEAILSWQK QQEGCFGEPD AEDEELSKAI
301 QYQQHFSRRV KRREKQFPDS RSVAQAGVQW RNLGSLQPLP PGFKQFSCLI LPSSWDYRSV
361 PPYLANFYIF LVETGFHHVA HAGLELLISR DPPTSGSQSV GLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C16orf89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 215 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 215 nTPM
- lung: 102 nTPM
- epididymis: 82 nTPM
- stomach: 78 nTPM
- gallbladder: 42 nTPM
- salivary gland: 33 nTPM
Single-cell type
- alveolar cells type 2: 263 nCPM
- transitional alveolar cells: 240 nCPM
- epididymal principal cells: 203 nCPM
- gastric chief cells: 141 nCPM
- respiratory secretory cells: 99 nCPM
- mucous neck cells: 82 nCPM
Immune cell
- basophil: 0.4 nTPM
- neutrophil: 0.2 nTPM
- memory B-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
- NK-cell: 0.1 nTPM
Brain region
- thalamus: 23 nTPM
- white matter: 22 nTPM
- basal ganglia: 20 nTPM
- medulla oblongata: 17 nTPM
- hypothalamus: 17 nTPM
- amygdala: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.7
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.51
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4735
- Domain of unknown function (DUF4735)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C16orf89 as an antibody target. Whether an autoantibody or antibody against C16orf89 could matter depends on whether native C16orf89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C16orf89 is annotated as secreted, so native C16orf89 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label C16orf89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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