C16orf86
Uncharacterized protein C16orf86
Also known as: CP086_HUMAN, FLJ41802
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZW13
- Gene
- C16orf86
- Ensembl
- ENSG00000159761
- Chromosome
- 16
- Canonical length
- 317 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C16orf86 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
317 residues, UniProt reviewed canonical sequence.
>Q6ZW13|C16orf86
1 MASAGAERRP GVQEATVVGQ GQLTEEPGSA QTSECPVAGD QFLVPAHEAR GTQSEDQRPA
61 GAASESELQE EGPKLGEERP KPHAGALEER GPRPVVSIVR PRHGPKRKPV KSLSLPGLRA
121 HLKAEAELPP KLPLQEEEPE DSQSEPSPSA KQHKKAKKRK SLGAPVLHAV ASMVSAPLET
181 LRLERKAQRL RPLYQYVNYC NPELNQAGKG DGEAEVEAEA ELAPVPEEGG VEQLQALLPL
241 AGELGPGLAL PCPSPLVTPT HALAPLGEEA GEEPGGLPSL GVSDHKAEVD KSTQVDIDKM
301 LSVCTAPLVP PLSPQYKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C16orf86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 38 nTPM
Expression across tissuesHPA
Tissue
- testis: 38 nTPM
- cerebellum: 10 nTPM
- kidney: 5.1 nTPM
- choroid plexus: 4.8 nTPM
- skeletal muscle: 4.5 nTPM
- colon: 3.9 nTPM
Single-cell type
- late primary spermatocytes: 250 nCPM
- early spermatids: 111 nCPM
- early primary spermatocytes: 31 nCPM
- late spermatids: 21 nCPM
- platelets: 18 nCPM
- decidual stromal cells: 13 nCPM
Immune cell
- plasmacytoid DC: 7.4 nTPM
- myeloid DC: 3.8 nTPM
- naive B-cell: 3.6 nTPM
- eosinophil: 3 nTPM
- classical monocyte: 2.3 nTPM
- memory B-cell: 1.9 nTPM
Brain region
- medulla oblongata: 3.1 nTPM
- white matter: 3.1 nTPM
- hypothalamus: 2.8 nTPM
- midbrain: 2.4 nTPM
- amygdala: 2.3 nTPM
- thalamus: 2.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.04
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.8
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4691
- Domain of unknown function (DUF4691)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C16orf86 as an antibody target. Whether an autoantibody or antibody against C16orf86 could matter depends on whether native C16orf86 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C16orf86 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C16orf86 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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