Seroatlas · Human Serome Atlas

C16orf82

Protein TNT

Also known as: TNT_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2V1
Gene
C16orf82
Canonical length
217 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for C16orf82 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q7Z2V1|C16orf82
     1  MSLVPGQHCS PSHTRLHLTS PITMGTEPAT QNTEFSKGSL IYGVTSPQRG HSQHSEASQG
    61  PLSLDKPLQL PPIFLEGEKG ESSVQNEQEG EPSLQSPSLE LQSPAWPRHA GVAQEPLKVS
   121  SSYLSDTQSS ESHVSSVQHP RPEEGSHASL SSGYAGDKEG SDISLVGSHR RVRLNRRLNT
   181  QAASNQTSQL GSIDPPSSLK SRLTGPAHST KQTGGKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C16orf82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
265 nTPM

Expression across tissuesHPA

Tissue

  • testis: 265 nTPM
  • pituitary gland: 0.3 nTPM
  • hypothalamus: 0.2 nTPM
  • prostate: 0.2 nTPM
  • breast: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM

Single-cell type

  • late spermatids: 9,209 nCPM
  • early spermatids: 1,148 nCPM
  • late primary spermatocytes: 298 nCPM
  • leydig cells: 13 nCPM
  • early primary spermatocytes: 9.8 nCPM
  • peritubular myoid cells: 9.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.6 nTPM
  • midbrain: 0.4 nTPM
  • pons: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4694
  • Domain of unknown function (DUF4694)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C16orf82 as an antibody target. Whether an autoantibody or antibody against C16orf82 could matter depends on whether native C16orf82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C16orf82 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C16orf82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C16orf82. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...