Seroatlas · Human Serome Atlas

C16orf78

Uncharacterized protein C16orf78

Also known as: CP078_HUMAN, MGC33367

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTQ4
Gene: C16orf78
Ensembl: ENSG00000166152
Chromosome: 16
Canonical length: 265 aa
Protein class: Predicted intracellular proteins
Subcellular location: Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q8WTQ4|C16orf78
     1  MSEQQMDLKD LMPTKRKYMW KTAEDRRMSD LTCVLEWLER RQGKKKQAPE KQKPKVVTVL
    61  KRNKKKEEKK GKGLMTARGG NRRDTETSQQ ALGKRFRKDA ASYRSLYGVE QKGKHLSMVP
   121  GSYIKDGPKK SDTDIKDAVD PESTQRPNPF RRQSIVLDPM LQEGTFNSQR ATFIRDWSNK
   181  MPDMAYERKL KSLMEKSTEP KMETMRMLKP EEVLSCRYLR LSKENIRTLL KLCKDAGMNV
   241  DIHPHMVEED IDAKKVFTGI PSMAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C16orf78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 3,113 nCPM
early spermatids: 456 nCPM
late primary spermatocytes: 28 nCPM
leydig cells: 2.4 nCPM
epididymal clear cells: 2 nCPM
parietal cells: 1.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.3 nTPM
white matter: 0.2 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4638
Domain of unknown function (DUF4638)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C16orf78 as an antibody target. Whether an autoantibody or antibody against C16orf78 could matter depends on whether native C16orf78 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C16orf78 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C16orf78 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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