Seroatlas · Human Serome Atlas

C16orf74

Uncharacterized protein C16orf74

Also known as: CP074_HUMAN, MGC17624

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GX8
Gene
C16orf74
Ensembl
ENSG00000154102
Chromosome
16
Canonical length
76 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Centrosome

OverviewNCBI Gene

No narrative summary is available for C16orf74 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>Q96GX8|C16orf74
     1  MGLKMSCLKG FQMCVSSSSS SHDEAPVLND KHLDVPDIII TPPTPTGMML PRDLGSTVWL
    61  DETGSCPDDG EIDPEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C16orf74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • retina: 26 nTPM
  • urinary bladder: 17 nTPM
  • spleen: 16 nTPM
  • vagina: 14 nTPM
  • cervix: 12 nTPM
  • hippocampal formation: 12 nTPM

Single-cell type

  • cone photoreceptor cells: 300 nCPM
  • rod photoreceptor cells: 286 nCPM
  • retinal bipolar cells: 231 nCPM
  • oocytes: 216 nCPM
  • syncytiotrophoblasts: 146 nCPM
  • prostatic hillock cells: 137 nCPM

Immune cell

  • naive B-cell: 50 nTPM
  • memory B-cell: 47 nTPM
  • eosinophil: 22 nTPM
  • myeloid DC: 18 nTPM
  • T-reg: 18 nTPM
  • classical monocyte: 17 nTPM

Brain region

  • hippocampal formation: 14 nTPM
  • cerebral cortex: 13 nTPM
  • basal ganglia: 6.2 nTPM
  • amygdala: 6 nTPM
  • choroid plexus: 4.8 nTPM
  • thalamus: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0.5
gnomAD missense Z
-0.77
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4597
  • Domain of unknown function (DUF4597)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C16orf74 as an antibody target. Whether an autoantibody or antibody against C16orf74 could matter depends on whether native C16orf74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C16orf74 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C16orf74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C16orf74. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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