Seroatlas · Human Serome Atlas

C16orf54

Transmembrane protein C16orf54

Also known as: CP054_HUMAN, FLJ35681

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWD8
Gene
C16orf54
Ensembl
ENSG00000185905
Chromosome
16
Canonical length
224 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q6UWD8|C16orf54
     1  MPLTPEPPSG RVEGPPAWEA APWPSLPCGP CIPIMLVLAT LAALFILTTA VLAERLFRRA
    61  LRPDPSHRAP TLVWRPGGEL WIEPMGTARE RSEDWYGSAV PLLTDRAPEP PTQVGTLEAR
   121  ATAPPAPSAP NSAPSNLGPQ TVLEVPARST FWGPQPWEGR PPATGLVSWA EPEQRPEASV
   181  QFGSPQARRQ RPGSPDPEWG LQPRVTLEQI SAFWKREGRT SVGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C16orf54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 39 nTPM
  • lymph node: 20 nTPM
  • tonsil: 19 nTPM
  • appendix: 14 nTPM
  • spleen: 14 nTPM
  • thymus: 12 nTPM

Single-cell type

  • neutrophils: 138 nCPM
  • plasma cells: 63 nCPM
  • innate lymphoid cells: 59 nCPM
  • nk-cells: 51 nCPM
  • t-cells: 45 nCPM
  • neutrophil progenitors: 43 nCPM

Immune cell

  • neutrophil: 559 nTPM
  • eosinophil: 381 nTPM
  • basophil: 295 nTPM
  • NK-cell: 225 nTPM
  • gdT-cell: 225 nTPM
  • memory CD4 T-cell: 220 nTPM

Brain region

  • white matter: 6.4 nTPM
  • medulla oblongata: 5.8 nTPM
  • cerebral cortex: 5.6 nTPM
  • pons: 5.5 nTPM
  • thalamus: 5.3 nTPM
  • cerebellum: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0.37
gnomAD missense Z
0.45
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4689
  • Domain of unknown function (DUF4689)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C16orf54 as an antibody target. Whether an autoantibody or antibody against C16orf54 could matter depends on whether native C16orf54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C16orf54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C16orf54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C16orf54. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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