C16orf46
Uncharacterized protein C16orf46
Also known as: CP046_HUMAN, FLJ32702
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P387
- Gene
- C16orf46
- Ensembl
- ENSG00000166455
- Chromosome
- 16
- Canonical length
- 395 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
395 residues, UniProt reviewed canonical sequence.
>Q6P387|C16orf46
1 MDLCQKNETD LENAENNEIQ FTEETEPTYT CPDGKSEKNH VYCLLDVSDI TLEQDEKAKE
61 FIIGTGWEEA VQGWGRTSPA ACIWPRKIPK KARVGEGACS DCLVCVNLSH WSLQTKPPTE
121 GGPEKDQSSP SQTQAAPQGP STASRAISDI CFPTYFRAEK KSLQIKEFIW CNKDWAIPGT
181 NRGKASGNPS GGAHRGLSIP GPLTSRALLV LPPLKASLSN ALDVLGKKSK NSFLQSEEKV
241 LDVEKDGCVA YAYGLKTADG KGEKRASELA KHPMVNDTPS SPSPAAQISL LTDPEQRCLH
301 WSLLSEKNLA CPPDPSNVRY LAALQLLQKR GVQSYKSKFK AKEPRSPVIT RKHVLPKAKQ
361 ENRPQMLETK VFPRPVLPSL TVSRVIIPVS THRILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C16orf46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 5.5 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.5 nTPM
- choroid plexus: 2.6 nTPM
- thyroid gland: 2.6 nTPM
- fallopian tube: 2.5 nTPM
- midbrain: 2 nTPM
- hippocampal formation: 1.9 nTPM
Single-cell type
- late spermatids: 15 nCPM
- early spermatids: 13 nCPM
- late primary spermatocytes: 4 nCPM
- fallopian tube ciliated cells: 3.3 nCPM
- epididymal efferent duct ciliated cells: 2.1 nCPM
- endometrial ciliated cells: 1.1 nCPM
Immune cell
- MAIT T-cell: 0.3 nTPM
- eosinophil: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 6.6 nTPM
- cerebral cortex: 3.4 nTPM
- white matter: 3 nTPM
- midbrain: 2.9 nTPM
- hippocampal formation: 2.8 nTPM
- hypothalamus: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.42
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4529
- Protein of unknown function (DUF4529)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C16orf46 as an antibody target. Whether an autoantibody or antibody against C16orf46 could matter depends on whether native C16orf46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C16orf46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C16orf46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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